lymphoid malignancies Flashcards
what does it mean when a lymhoma is AgR positive
that it is a mature neoplasia (grown up B or T cell)
what receptors does a B cell express
CD19, CD20, CD79, slg
what receptors does a NK cell express
CD16 or CD56
what receptors does a T cell express
CD3
which lymphoma often has an T(14;18) translocation?
follicular lymphoma
which lymphoma often has an T(11;14) translocation?
mantle cell lymphoma
which lymphoma often has an T(8;14) translocation?
burkitt lymphoma
which lymphoma often has B symptoms
nodal lymphoma
what are B symptoms
fever greater than 38 degree, night sweats and unintentional weight loss of >10% of the normal body weight
what lymphomas are often recognized quite late due to the place that the tumour grows
extra nodal tumours
what is the most common type of leukaemia
CLL
what is the most common childhood malignancy
burkitt lymphoma
what is the second most common NHL, which often occurs later in life and is due to a T(14:18)
follicular lymphoma
what is the most common B cell lymphoma (37%), has a male predomincance, localised in germinal centre, due to T(3;4) (BCL6)
diffuse large B cell lymphoma
which lymphoma has an peak incidence between 16 and 65, is linked to EBV and of the type reed sternberg
hodgkins lymphoma
