myeloid malignancies

Question 1

in which three groups are myeloid malignancies divided

Answer 1

disorders of proliferation
disorders of differentiation
disorders of differentiation and proliferation

Question 2

give an example of an myeloid disorder of proliferation

Answer 2

chronic myeloid leukaemia

Question 3

give an example of an myeloid disorder of proliferation and differentiation

Answer 3

acute myeloid leukaemia

Question 4

peak incidence after 60, fatigue, breathlessness, pallor, cardiag flow murmur, fever, gum bleeding, hypoxia, headache, bleeding, renal stones and infections

Answer 4

acute myeloid leukaemia

Question 5

peak incidence 53 years, fatigue, weight loss, asymptomatic, splenomegaly, hepatomegaly, anaemia, thrombocytis

Answer 5

chronic myeloid leukaemia

Question 6

how do you treat CML

Answer 6

tyrosine kinase inhibitors

Question 7

due to which famous mutation can CML arrise

Answer 7

Philadelphia chromosome; BCR and ABL make a fusion protein now (9 and 22)

Question 8

what are class 1 mutations in AML

Answer 8

mutations that give a proliferative advantage

Question 9

what are class 2 mutation in AML

Answer 9

mutations that give a differentiation stop

Question 10

what type of AML is often therapy related

Answer 10

dysplasia