diagnostics Flashcards
1
Q
what is used to show a BRAF mutation
A
field markers
2
Q
aneuploidy
A
multiplication or loss of chromosomes
3
Q
describe the BRAF pathway
A
RAS activates BRAF which activetes MEK which activates ERK which causes nervus or melanoma formation
4
Q
describe the EGFR pathway
A
EGFR is bound by a ligand and phosphorylated. it activats KRAS and PI3K which will cause proliferation
5
Q
how do TKI (first line) work
A
TKI block phosporhylation of EGFR and thus the pathways will be inhibited. they compete with ATP
6
Q
osimertinib
A
TKI that works regardless of a T790 mutation
7
Q
T790 mutation
A
additional mutation that makes EGFR resistant against TKI of the first line
8
Q
on which exon are EGFR mutations often
A
exon 19
