heterogeneity

Question 1

heterogeneity

Answer 1

the observation that different tumour cells can show distinct morphological and phenotypic profiles

Question 2

intratumour

Answer 2

several clones within the same tumor mass

Question 3

intertumor

Answer 3

wihtin same patient different tumours

Question 4

interpatient

Answer 4

between patients different tumours

Question 5

which tumours have more clonal heterogeneity in their tumours

Answer 5

DNA repair deficient missing

Question 6

what selective pressures are tumours clones under

Answer 6

immune recognition
copetition for nutrients and oxygen
inter clonal competition

Question 7

explain the relation between intratumor en intertumor heterogeneity

Answer 7

intratumor geneity –> more clones –> more different metastasis –> intertumor heterogeneity

Question 8

which tumor can have a 5 FU treatment and thus have a better prognosis

Answer 8

MMR proficient tumours

Question 9

driver genes

Answer 9

non silent

Question 10

which mutations dominate the individual mutation profiles often

Answer 10

passenger mutations

Question 11

explain why KRAS and BRAF mutations offten wil not occur in the same pathway

Answer 11

they are both oncogenes and in the same pathway, thus one mutation is enough te instabilize the pathway