Systemic sclerosis

Question 1

Characteristic feature of systemic sclerosis

Answer 1

hardened, sclerotic skin and other connective tissues.

Question 2

Female:male ratio

Answer 2

4:1

Question 3

3 patterns of systemic sclerosis

Answer 3

Limited
Diffuse
Scleroderma

Question 4

Limited systemic sclerosis

Answer 4

Raynaud’s
scleroderma

a subtype = CREST syndrome: Calcinosis
Raynaud’s phenomenon, oEsophageal dysmotility, Sclerodactyly
Telangiectasia

Question 5

Limited systemic sclerosis is associated with which antibody

Answer 5

anti-centromere antibodies

Question 6

Diffuse cutaneous systemic sclerosis clinical features

Answer 6

scleroderma affects trunk and proximal limbs
Respiratory involvement
- ILD, pulmonary hypertension
Renal disease
Hypertension

Question 7

Diffuse cutaneous systemic sclerosis is associated with which antibody

Answer 7

anti scl-70 antibodies

Question 8

Diffuse cutaneous systemic sclerosis prognosis

Answer 8

Poor

Question 9

Clinical features of scleroderma

Answer 9

tightening and fibrosis of skin
may be manifest as plaques (morphoea) or linear

no internal organ involvement