ANCA vasculitis Flashcards

1
Q

What does ANCA stand for

A

Anti-neutrophil cytoplasmic antibodies (ANCA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

give examples of small-vessel ANCA associated vasculitides

A

granulomatosis with polyangiitis (Wegner’s)
eosinophilic granulomatosis with polyangiitis (Churg-Strauss)
microscopic polyangiitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

ANCA associated vasculitis is more common with increasing age TRUE/FALSE?

A

TRUE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Name clinical findings which are common to all ANCA associated vasculitis

A

Renal impairment (immune complex glomerulonephritis)
Respiratory symptoms - dyspnoea/ haemoptysis
Systemic symptoms - fatigue/fever/weight loss
vasculitic rash (rare)
sinusitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

First line investigations for ANCA vasculitis

A

urinalysis- haematuria/proteinuria
bloods:
- U&E for renal function
- FBC for normocytic anaemia/thrombocytosis
- CRP: raised
- ANCA testing
CXR: nodular, fibrotic or infiltrative lesions may be seen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Name the two types of ANCA

A

cytoplasmic (cANCA)
perinuclear (pANCA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

cANCA is associated with which small vessel vasculitis

A

Granulomatosis with Polyangitis (GPA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

pANCA is associated with which small vessel vasculitis?

A

Eosinophilic granulomatosis with polyangiitis (Churg Strauss)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Microscopic polyangiitis is associated with both c-ANCA and p-ANCA. Which is mroe prevalent?

A

p-ANCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

c-ANCA acts on which target. PR3 or MPO?

A

PR3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

pANCA acts on which target. PR3 or MPO?

A

MPO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which ANCA can be used to somewhat monitor disease activity?

A

c-ANCA levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Other conditions associated with p-ANCA

A

Ulcerative colitis (70%)
Primary sclerosing cholangitis (70%)
Anti-GBM disease (25%)
Crohn’s disease (20%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What organ biopsies can be used to aid diagnosis of ANCA vasulitis?

A

Kidney or lung biopsies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Management of ANCA associated vasculitis

A

Immunosuppressant treatment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q
A