Azathioprine Flashcards
1
Q
Describe how Azathioprine works
A
metabolised to the active compound mercaptopurine
- a purine analogue that inhibits purine synthesis
2
Q
Test used to check if individuals are prone to azathioprine toxicity
A
A thiopurine methyltransferase (TPMT) test
3
Q
Adverse effects of azathioprine
A
bone marrow suppression
nausea/vomiting
pancreatitis
increased risk of non-melanoma skin cancer (SCC/BCC)
4
Q
With what drug does azathioprine have a significant interaction in which case the dose of azathioprine must be reduced?
A
allopurinol
5
Q
Is Azathioprine safe to use in pregnancy?
A
Yes
6
Q
A
