Sjogren's syndrome

Question 1

Sjogrens is an autoimmune condition affecting what?

Answer 1

exocrine glands
=> causes dry mucosal surfaces.

Question 2

What conditions can cause secondary sjogrens

Answer 2

• rheumatoid arthritis
• other connective tissue disorders

Question 3

How long does it take for secondary sjogrens to develop?

Answer 3

around 10 years after initial condition onset

Question 4

Female:male ratio

Answer 4

9:1

Question 5

With sjogrens there is a marked increased risk for which type of malignancy

Answer 5

lymphoid malignancy (40-60 fold).

Question 6

Clinical features

Answer 6

keratoconjunctivitis sicca
dry mouth
vaginal dryness
arthralgia
Raynaud’s, myalgia
sensory polyneuropathy
recurrent episodes of parotitis
renal tubular acidosis

Question 7

What autoantibodies are positive in sjogrens?

Answer 7

rheumatoid factor (RF)
ANA
anti-Ro
anti-La

Question 8

Histology findings

Answer 8

focal lymphocytic infiltration

Question 9

Management of sjogrens

Answer 9

artificial saliva and tears
pilocarpine may stimulate saliva production