Systemic Immunologic Diseases (34)

Question 1

What is a systemic immune disease?

Answer 1

autoimmune disease that involve multiple organ systems

Question 2

Diseases typically originate from a local autoimmune response may only affect a _____ organ

Answer 2

single

Question 3

What does systemic immune disease lead to?

Answer 3

immune complex formation and multi-organ damage

Question 4

Systemic immune disease preferentially affect the ______

Answer 4

capillary beds

Question 5

What parts of the body are generally affected from systemic immune diseases?

Answer 5

skin, ct, muscles, joints, kidneys

Question 6

What is systemic lupus erythematosus (SLE)?

Answer 6

autoimmune reactions directed against constituents of cell nucleus and DNA

chronic multisystem inflammatory disease that affects the skin, joints, etc

Question 7

What is the pathogenesis of SLE?

Answer 7

results from interactions among genetic, drug, environmental, and immunologic factors

apoptotic cells from affected patients are not cleared normally through phagocytosis

Question 8

Patients with SLE develop auto-antibodies to ____ and ______

Answer 8

auto-antibodies to DNA
and cell nuclear components

Question 9

Autoantibodies in SLE lead to damage through several mechanisms. List one

Answer 9

type 3 hypersensitivity

Question 10

What is the signalment for SLE?

Answer 10

areas most exposed to UV light
skin with epithelial turnover
Shelties & Collies - male and female

Question 11

Dogs with SLE have common clinical manifestations of _____

Answer 11

skin/muscles (non-erosive polyarthritis), lining of lungs, heart, nervous tissue, and kidneys

dermatologic signs

Question 12

T/F: No single test is definitive for SLE

Answer 12

TRUE - this is true for most diseases

Question 13

Which 3 laboratory tests are supportive for SLE?

Answer 13

LE preps - blood allowed to clot

positive ANA antibody found

biopsy

Question 14

What is the most common diagnostic test for SLE?

Answer 14

ANA (antinuclear antibody)

uses mouse liver cells as the capture antigen on the slide

patient’s anti-nuclear antibody, if present, binds to antigen

Question 15

What is the treatment for SLE?

Answer 15

immunosuppressive therapy
plasmapheresis ( filters blood)

Question 16

What is discoid lupus erythematosus?

Answer 16

mild variant of SLE

affects same areas where lupus starts

Question 17

What is different about test results with discoid lupus erythematosus?

Answer 17

ANA/LE tests negative

Question 18

What is autoimmune polyarthritis?

Answer 18

diseases marked by joint pathology and secondary systemic signs

Question 19

What is the most important variant of autoimmune polyarthritis in domestic species?

Answer 19

non-erosive

Question 20

What are the 3 major groups of non-erosive polyarthritis?

Answer 20

Question 21

Review the types of idiopathic polyarthritis

Answer 21

Question 22

What is the signalment for idiopathic polyarthritis?

Answer 22

most common in male dogs

Question 23

What is dermatomyositis?

Answer 23