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Immunology > Exam 1 Straight Memorization - End E1 > Flashcards

Exam 1 Straight Memorization - End E1 Flashcards

1
Q

Which TLRs are intracellular?

A

3, 7, 8, 9, 10 (and 13)

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2
Q

Which TLRs are extracellular i.e. cell surface?

A

1, 2, 4, 5, 6, 11, 12

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3
Q

What is the ligand for TLR 1? Pathogens recognized?

A

triacylated lipoprotein
bacteria

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4
Q

What is the ligand for TLR 2? Pathogens recognized?

A

lipoproteins
bacteria, viruses, parasites

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5
Q

What is the ligand for TLR 3? Pathogens recognized?

A

dsRNA
viruses

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6
Q

What is the ligand for TLR 4? Pathogens recognized?

A

LPS
bacteria, viruses`

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7
Q

What is the ligand for TLR 5? Pathogens recognized?

A

flagellin
bacteria

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8
Q

What is the ligand for TLR 6? Pathogens recognized?

A

diacylated lipoprotein
bacteria, viruses

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9
Q

What is the ligand for TLR 7? Pathogens recognized?

A

ssRNA, guanosine
viruses, bacteria

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10
Q

What is the ligand for TLR 8? Pathogens recognized?

A

ssRNA
viruses, bacteria

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11
Q

What is the ligand for TLR 9? Pathogens recognized?

A

CpG DNA, dsDNA
viruses, bacteria, protozoa

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12
Q

What is the ligand for TLR 10? Pathogens recognized?

A

regulates TLR2 responses
suppresses inflammation

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13
Q

What is the ligand for TLR 11? Pathogens recognized?

A

profilin and flagellin
protozoa, bacteria

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14
Q

What is the ligand for TLR 12? Pathogens recognized?

A

profilin
protozoa

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15
Q

What is the ligand for TLR 13? Pathogens recognized?

A

unmethylated RNA
bacteria

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16
Q

What are cytokines that mediate and regulate innate immunity?

A

IL-1
IL-6
TNF-alpha
IL-12
Type I interferons

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17
Q

What is the function of IL-1, IL-6, and TNF-alpha in mediating and regulating innate immunity?

A

pro-inflammatory cytokines

18
Q

What is the function of IIL-12 in mediating and regulating innate immunity?

A

produced by APCs in response to bacteria and viruses
activate NK cells to be more efficient killers
induce IFN-gamma production
stimulate differentiation of TH1 cells

19
Q

What is the function of Type 1 interferons in mediating and regulating innate immunity?

A

antiviral activity

20
Q

What are the cytokines that mediate and regulate adaptive immunity?

A

IL-2
IL-4
IL-5
IL-10
IL-13
TGFbeta
IFNgamma
TNF

21
Q

What are the cytokines that mediate and regulate adaptive immunity by regulation of lymphocyte activation, growth, and differentiation?

A

IL-2
IL-4
IL-13
IL-10
TGFbeta
IFNgamma

22
Q

What is the function of IL-2?

A

lymphocyte proliferation

23
Q

What is the function of IL-4?

A

stimulate TH2, B cell differentiation (IgE)

24
Q

What is the function of IL-13?

A

B cell differentiation (IgE)

25
Q

What is the function of IL-10?

A

Inhibit TH1

26
Q

What is the function of TGF-beta?

A

Treg cytokine, B cell differentiation (IgA)

27
Q

What is the function of IFN-gamma (mediating and regulating lymphocyte activate, growth, and differentiation)?

A

B cell differentiation (IgG)

28
Q

What are the cytokines that mediate and regulate adaptive immunity by enhancing innate immunity?

A

IFN-gamma
TNF
IL-5

29
Q

What is the function of TNF?

A

activate endothelial cells, neutrophils

30
Q

What is the function of IFN-gamma (in enhancing innate immunity)?

A

activate macrophages, neutrophils, NK cells

31
Q

What is the function of IL-5?

A

eosinophil activation and generation

32
Q

What are the cytokines that stimulate hematopoiesis?

A

erythropoietin
thrombopoietin, IL-11
IL-3
IL-5
GSM-CSF
G-CSF
M-CSF

33
Q

What is the function of erythropoietin?

A

stimulate production and differentiation of red blood cells

34
Q

What is the function of thrombopoietin and IL-___?

A

stimulate platelet production
IL-11!

35
Q

What is the function of IL-3 (hematopoiesis)?

A

stimulate bone marrow production of white blood cells

36
Q

What is the function of IL-5 (hematopoiesis)?

A

stimulates eosinophil differentiation during parasite infection/allergic response
antagonists used in eosinophilia and asthma

37
Q

What is the function of GSM-CSF?

A

stimulate differentiation of neutrophil and monocyte

38
Q

What is the function of G-CSF?

A

stimulate differentiation of neutrophils

39
Q

What are the cytokines limited to TH1?

A

IL-2
IFN-gamma
TNF-alpha

40
Q

What are the cytokines limited to TH2?

A

IL-4
IL-5
IL-9
IL-13

Immunology (36 decks)

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