System interactions Flashcards
What are risk factors that can contribute to obesity
Sedentary lifestyle
genetic predisposition
medications that increase appetite or food cravings high glycemic diet
environmental factors: smoking cessation stress abuse history
underlying illness
What illness is predispose individuals to obesity
Polycystic ovarian syndrome
Cushing’s disease
hypothyroidism
Prader Willi syndrome
What are cardiac physiologic changes that are commonly associated with obesity
Cardiomyopathy heart failure abnormal ventricular remodeling hypertrophy atrial fibrillation dysrhythmias
What are pulmonary physiologic changes that are commonly associated with obesity
obstructive sleep apnea,
asthma,
hypoventilation syndrome
What are kidney physiologic changes that are commonly associated with obesity
Decreased renal perfusion
What are Genitourinary physiologic changes that are commonly associated with obesity
Urinary incontinence
infertility
What are vascular physiologic changes that are commonly associated with obesity
Altered cardiac output and stroke volume hypertension varicosities increase total blood volume Venous insufficiency
What are MSK physiologic changes that are commonly associated with obesity
Osteoarthritis
altered mobility patterns
What are Adipose tissue, liver , pancreas physiologic changes that are commonly associated with obesity
increased adipokine production, fatty liver disease insulin resistance type two diabetes
Is the best way to address a child’s Appearance of extra weight and the long-term health concerns
Conversation with child’s pediatrician is best way to determine if extra weight is truly a long-term concern
When is a child considered overweight? Obese?
overweight 85-94 percentiles
Obese over 95 percentile
Important factors when characterizing patients with obesity risks
BMI ]
hip to waist ratio
distribution of body fat
waist circumference
What is lipedema
Undefined ideology affecting physical size and distribution of adipose cells in the body.
Appears in lower extremities of woman.
Sometimes appears as big legs and unsymmetrical body disproportions.
Patient should be educated and realistic outcome expectations and not assume weight loss or fix overall morphological proportion.
Exercise will help some
Pear shape
Gluteal femoral obesity
peripheral fat distribution
common in women
associated with lower incidence of obesity related risk factors
Apple shape
Central fat distribution
abdominal obesity
highly correlated with cardiovascular disease type 2DM
attributed to higher percentage of metabolically active visceral fat
True or false waist circumference measures may be better predictors of diabetes and cardiovascular risk then BMI alone
true central obesity= > 40 males > 36 females hip to waist ratio >1 males >.85 females
Carbohydrates
- Needed for high intensity exercise
- poor carbohydrate intake leads to protein consumption
- main source of feul for the CNS
- Simple carbs increase blood glucose
- complex carbs need to be broken down before they are used, increase BG levels slower
- glycemic index indicates how fast BG level will increase depending on carb breakdown
Fats
- Primary fuel source for low intensity exercise
- Help protect organs, insulte body, help transport fat soluble vitamins
- Saturated fats- animal fat, bad cholesterol LDL
- non satureated fats: plant based fat, good cholesterol HDL
Protein
- responsible for growth, and maintenance of body tissue
- skin ligaments and muscle
- .8 grams/ kilogram
- There are 20 amino acids, 9 of them are essential amino acids which cant be produced by the body
can vitamins be prodiced by the body?
no
fat soluble vitamins
A D E K
- absorbed by intestinal tract
- stored in liver and fatty tissues
- proteins carry vitamins thro body
- may reach toxic levels
Vitamin a
Essential for eyes, epithelial tissue growth development and reproduction.
Deficiency: nights blindness rough dry skin growth failure
Toxicity: appetite loss hair loss and enlarged liver/spleen
Vitamin D
Increases blood flow levels of calcium and phosphorus
Deficiency: faulty bone growth, rickets, osteomalacia.
Toxicity calcification of soft tissue, hypercalcemia
Vitamin E
Antioxidant in cell membranes. Important for cell integrity for lungs and red blood cells
Toxicity: Breakdown of RBC
Deficiency: Decreased thyroid hormone increased triglycerides
Vitamin K
Necessary for at least two blood clotting proteins
Toxicity: Hemorrhage and defective blood clotting
Deficiency: cant happen
What are water soluble vitamins
Vitamin B2 riboflavin vitamin B3 Niacin vitamin B6 Pyridoxine Vitamin B12 cobalamin vitamin C biotin choline folic acid
What is recommended intake for fruits a day ?
1.5 - 2 cups per day.
One cup = cup of fruit, fruit juice or 1/2 of cup of dried fruit
What is recommended intake for veggies a day ?
2.5-3 cups/ day
One cup = cup of veggies or juice or 2 cups a raw leafy greens
What is recommended intake for grains a day ?
5-8 ounces
1 ounce = 1 bread slice, cup of ceral, 1/2 cup of cooked pasta or rice
whole grains recommended
What is recommended intake for protein a day ?
5-6.5 ounces
Ounce = cup of meat poultry fish, one egg. 1/2 ounce of nuts or seeds or 1/4 cup of cooked beans
What is recommended intake for dairy a day ?
3 cups/ day
what physiological changes occur with pregnancy
weight gain 25-35 lbs
uterus ascends into ab cavity and becomes ab organ
rib expansion to make room for uterus
diaphragm elevates 4 cm
- increased depth of respiration, tidal volume, min ventilation
- increased O2 consumption 15-20% blood volume 40-50% and CO 30-60%
what p postural changes occur with pregnancy
- hypotension in supine
- ab become overstretched
- ligs become lax
- joints are hypermobile
what is the recommended exercise during pregnancy
30 mins at 50-60 of max HR loose clothing NWB avoid becoming overtired and stay hydrated avoid supine p. 1st trimester
when is exercise not safe during pregnancy - relative contraindications
Relative:
- Severe anemia
- unevaluated cardiac disease disarrhythmia
- chronic bronchitis
- BMI < 12
- extreme sedentary lifestyle
- intrauterine growth restriction in current preg
- poor controlled HTN
- orthopedic limitation
- poorly controlled seizures, hypothyroidism, Diabetes 1, -HTN
- heavy smoker
when is exercise not safe during pregnancy - absolute contraindications
- Sig hemodynamic heart disease
- restrictive lung dx
- incopetent cervix
- premature labure risk
- bleeding
- placenta previa @ 26 weeks
- preclampsia, preg induced HTN
how many more calories are required a day in pregnancy
300
if exercising, be aware
how should exercise be handed after dleivery
preg changes lst 4-6 weeks after delivery
how can you reduce pressure on the vena cava during preg?
left side lying
what types of exercises should be avoided in preg
- valsalva
- ab exercises may induce contractions
What are the three methods for in enteral administration
Oral: absorption into the G.I. track via mouth allows for gradual increase of drug levels that are unpredictable. Outside must be non-lipid soluble so it may pass the intestinal track and be absorbed by the lining and degraded by the liver. Lipid soluble capsule for ingestion
Sub lingual: under the tongue or between the cheek and gums so drug may be introduced to the venous circulation directly to the heart. Fast introduction four cases of acute pain like angina. Drug bypass his liver and is not overly metabolized.
Rectal administration: is for patients who are of unconscious. drugs are not absorbed as well through the rectal cavity compared to sublingual and oral
Which route of administration allows for 100% bio availability
Intravenous administration. Inserted into peripheral vein to enter bloodstream.
What is a benefit of drug inhalation for drug administration
Lungs offer large surface area for absorption and can enter systemic circulation rapidly. May irritate respiratory tract. Often used for treating pulmonary pathology
What is the difference between topical and transdermal drug administration routes
Topical administration is applied directly on the skin or mucous membranes. Poorly absorbed through the skin therefore is reserved for treating look like skin ear or nose disorders. Mucous membranes are able to absorb drug better and can be used to treat systemic conditions.
Transdermal: Drug is applied directly to the skin with the intention to absorb through skin and enter systemic circulation. Slow and controlled release of drug over long period of time. Use of patch through Intophoresis and phonophoresis. Drug cannot penetrate the skin if degraded by dermal enzymes.
Factors affect pharmacokinetics
Age. Weight. Genetics. Disease. Exercise. Medications. Food- The stomach will speed absorption into bloodstream.Food with medication to avoid gastric irritation.
Is the intention of intra-arterial administration for drugs
Intended to be injected in an artery to travel directly to target tissues. Difficult because drug is intended to act at specific site without affecting other tissues, chemotherapy
What types of drug administration routes administered with injection
Intravenous
intra-arterial
subcutaneous-Injection directly under the skin can be useful when slow release into systemic circulation is required. Can be affected with Lynn mobility cold heat or massage.
intramuscular - Drug injected directly into muscle absorbed faster than subcutaneous injection.
intrathecal- Injected directly into the sheath like spinal meninges for drug to affect CNS without passing BBB
Bio availability
Percent of drug available in systemic circulation from site of original administration.
Pharmacodynamics
Drug affects on the body on a cellular level
what to drug does to the body
Pharmacokinetics
How drugs are absorbed distributed metabolize and eliminated by the body
- what the body does to the drug
therapeutic index
Compares the therapeutic effect of the drug/effectiveness with lethal effects.
-Low TI indicates risky drug making patients taking his drugs being frequently monitored for adverse reactions.
Patient considerations for post surgical status with side effects of general anesthesia
Confusion and muscle weakness. Retention of pulmonary secretions; initiate breathing exercises or postural drainage with patient
What are considerations for a patient who has local anesthesia
- Spinal or local nerve block
- When using a transdermal patch, avoid using heat to avoid accelerated rate of absorption.
- Sensation and motor control may be diminished.
- Bracing may be needed, exercises should be performed cautiously.
What consideration should be made with anti-arthritic drugs and physical therapy
Glucocorticoid drugs can have catabolic affects that lead to break down a tendon bone in skin.
-Be cautious with stretching and strengthening exercises to reduce risk of fracture and soft tissue injury.
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