synaptic transmission Flashcards
rely on intracellular proteins that allow ions to flow passively between cells, very fast and bidirectional
electrical synapses
complex of 6 proteins that form a hemichannel - two hemichannels together forms a
gap junction
what components does a chemical synapse have
synaptic cleft, vesicles, and granules as well as NTs and peptides
electrical synapses have gap junctions where chemical have
active zones and pre and post synaptic membranes
is there a synaptic delay in chemical synapses?
yes
assymetrical, excitatory found on dendritic spines
grays spine I
symmetrical, inhibitory found dendritic shafts
grays spine II
first step in chemical synapse
transmitter is released and then stored in vesicles
second step in chemical synapse
action potential invades presynaptic terminal
third step in chemical synapse
depolarization of presynaptic terminal causes opening of voltage gated Ca 2+
fourth step in chemical synapse
influx of Ca2+
5 step in chemical synapse
ca causes vesicles to fuse with presynaptic membrane
6 step in chemical synapse
transmitter is released
7 step in chemical synapse
transmitter binds to receptor molecules in postsynaptic membranes
8 step in chemical synapse
opening or closing of postsynaptic channels
9 step in chemical synapse
postsynaptic current causes excitatory or inhibitory
three criteria for identifying a NT
- present within presynaptic neuron
- released in response to presynaptic depolarization
- specific receptors for NT on post synaptic cell
NT produced in ___ ____
axon terminals
enzymes needed for synthesis produced in cell body and must be transported to terminals via __ ___ __
slow axonal transport
neuropeptides are loaded into granules in cell body and transported down axon via ____ ____ __
fast axonal transport
cadmium is a __ ___ inhibitor
ca channel
SNARE proteins in vesicles are
V-SNARES
SNARE proteins in plasma membrane are
T-SNARES
SNARE proteins do or do not bind Ca
do not
Ca binds to _____ which leads to curvature of plasma membrane which brings membrane together
synaptotagmin
tetanus and botulinum sever attachment of
SNARE proteins