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molecular and cellular neuroscience > synaptic transmission > Flashcards

synaptic transmission Flashcards

1
Q

rely on intracellular proteins that allow ions to flow passively between cells, very fast and bidirectional

A

electrical synapses

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2
Q

complex of 6 proteins that form a hemichannel - two hemichannels together forms a

A

gap junction

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3
Q

what components does a chemical synapse have

A

synaptic cleft, vesicles, and granules as well as NTs and peptides

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4
Q

electrical synapses have gap junctions where chemical have

A

active zones and pre and post synaptic membranes

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5
Q

is there a synaptic delay in chemical synapses?

A

yes

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6
Q

assymetrical, excitatory found on dendritic spines

A

grays spine I

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7
Q

symmetrical, inhibitory found dendritic shafts

A

grays spine II

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8
Q

first step in chemical synapse

A

transmitter is released and then stored in vesicles

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9
Q

second step in chemical synapse

A

action potential invades presynaptic terminal

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10
Q

third step in chemical synapse

A

depolarization of presynaptic terminal causes opening of voltage gated Ca 2+

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11
Q

fourth step in chemical synapse

A

influx of Ca2+

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12
Q

5 step in chemical synapse

A

ca causes vesicles to fuse with presynaptic membrane

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13
Q

6 step in chemical synapse

A

transmitter is released

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14
Q

7 step in chemical synapse

A

transmitter binds to receptor molecules in postsynaptic membranes

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15
Q

8 step in chemical synapse

A

opening or closing of postsynaptic channels

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16
Q

9 step in chemical synapse

A

postsynaptic current causes excitatory or inhibitory

17
Q

three criteria for identifying a NT

A
  1. present within presynaptic neuron
  2. released in response to presynaptic depolarization
  3. specific receptors for NT on post synaptic cell
18
Q

NT produced in ___ ____

A

axon terminals

19
Q

enzymes needed for synthesis produced in cell body and must be transported to terminals via __ ___ __

A

slow axonal transport

20
Q

neuropeptides are loaded into granules in cell body and transported down axon via ____ ____ __

A

fast axonal transport

21
Q

cadmium is a __ ___ inhibitor

A

ca channel

22
Q

SNARE proteins in vesicles are

A

V-SNARES

23
Q

SNARE proteins in plasma membrane are

A

T-SNARES

24
Q

SNARE proteins do or do not bind Ca

A

do not

25
Q

Ca binds to _____ which leads to curvature of plasma membrane which brings membrane together

A

synaptotagmin

26
Q

tetanus and botulinum sever attachment of

A

SNARE proteins

molecular and cellular neuroscience (8 decks)

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