CSF and glymphatic system Flashcards
10% of the total fluid volume of the cranial cavity
CSF
12% of fluid in cranial cavity; in between cells
interstitial fluid
68% total fluid volume ( within cells)
intracellular
the body uses ___ system to remove waste from interstital spaces of your tissue
lymphatic
several organs are apart of lymphatic system
lymph nodes, thymus, spleen, tonsils, peyers patch
attached to brains surface by glial cells called astrocytes
pia mater
the lymphatic vessels of the brain are located where
meminges
lympathic vessles become extensive at base of brain and exit skull alongside ___ ____
cranial nerves
surrounds all exposed surfaces of CNS in subarachnoid space and within ventricles
CSF
how is CSF made
by specialized ependymal cells of choroid plexus
the blood brain barrier is highly permeable tp
water, co2, o2
the bbb is impermeable to
plasma proteins and non lipid soluble organic molecules
exceptions to bbb are
areas of hypothalamus and pineal gland
substances flow directly into interstitial fluid, tight junctions form between endothelial cells
BBB
substances flow from vascular (blood) to plexus; vascular surrounded by chorooid is leaky (cappilaries); tight junctions are formed by choroid plexus
BCSF (barrier CSF)
the choroid plexus is ____
polarized
there is a differential flow of subtabces in BCSF because it is polarized; what is transported in?
vitamins, organic nutrients, o2
fluid filtered from _____ by choroid plexus
blood
the CSF flows how
lateral ventricles to intraventricular foramen to third ventricle to aqueduct of midbrain to fourth ventricle
from the fourth ventricle CSF can flow into ___ ____ of spinal cord out to subarachnoid space
central canal
small protrusions of arachnoid through the dura mater into superior saggital sinus (venous blood flow)
arachnoid granulation
generall fluid only flows in one direction
from CSF to venous system
central blood vessels can chnage blood flow by altering diameter by ____ ___
smooth muscle
in cappilaries, constriction or dilation is done by ___
pericytes
CSF flows around a pwathway called ___ ____ space; between atrocyte endfeet becomes continuous with basil lamina and will forced into interstitial space
virchow-robin
what drives the movement of CSF
the heartbeat and smooth muscle/ pericytes surrounding arteries
smooth muscles cells surrounding arterioles generate ___ ___ as they contract
pulse waves
_____ act as carriers for cholesterol
apolipoproteins
the ___ system is turned off during waking hours
glymphatic
glymphatic activity ____ during aging
decreases
