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Pharmacology > Sympathomimmetics and Adrenergic Antagonists > Flashcards

Sympathomimmetics and Adrenergic Antagonists Flashcards

0
Q

Direct-acting nonselective sympathomimmetic used for neurogenic shock and LAST RESORT for cardiogenic shock

A

Norepinephrine

SE: extreme vasospasm, tissue necrosis, arrhythmia, REFLEX BRADYCARDIA

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1
Q

Direct-acting nonselective sympathomimmetic used as TOC for cardiac arrest, anaphylaxis, asthma, COPD and hemostasis

A

Epinephrine

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2
Q

Direct-acting nonselective sympathomimmetic used for cardiogenic shock and heart failure

A

Dopamine

SE: CVS disturbance, arrhythmias

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3
Q

Dose-dependent actions of Dopamine

A

Low-dose: 1-5 mcg/kg/min - increased UO due to increased renal blood flow -> D1 receptor

Medium-dose: 5-15 mcg/kg/min - inc renal blood flow, HR, cardiac contractility and CO via BETA 1

High-dose: >15 mcg/kg/min - vasoconstriction and inc BP via ALPHA rec.

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4
Q

Beta nonselective sympathomimmetic used for asthma

A

Isoproterenol

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5
Q

Selective Alpha1 agonist used as decongestant, drug-induced hypotension and spinal shock
SE: REBOUND HYPERTENSION

A

Phenylephrine
SimD: Pseudoephedrine

Unlike Atropine, it causes mydriasis w/o cycloplegia

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6
Q

Alpha2 selective sympathomimmetic antihyoertensive drug known to cause REBOUND HYPERTENSION

A

Clonidine

Treat REBOUND HPN with Phentolamine

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7
Q

Alpha2 selective sympathomimmetic used as TOC for preeclampsia

A

Methyldopa

SE: hemolytic anemia with positive Coomb’s test

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8
Q

Alpha2 selective sympathomimmetic used for glaucoma

A

Apraclonidine

SimD: Brimonidine

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9
Q

Beta1 selective sympathomimmetic used as TOC for acute HF and cardiogenic shock

A

Dobutamine

Used in cardiac stress testing

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10
Q

Beta2 selective sympathomimmetic used as TOC for acute asthma attacks

A

Albuterol/Salbutamol

May precititate arrhythmias in px wd concurrent COPD and heart dse

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11
Q

Beta2 selective sympathomimmetic used as TOC for preterm labor

A

Terbutaline and Ritodrine

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12
Q

Alpha nonselective adrenergic antagonist used as presurgical TOC for Pheochromocytoma

Forming covalent bond with Alpha receptors

A

Phenoxybenzamine

SE: Orthostatic hypotension, reflex tachycardia

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13
Q

Alpha nonselective adrenergic antagonist used as antidote to a1 agonist overdose, REBOUND HYPERTENSION and as presurgical Tx for Pheochromocytoma

A

Phentolamine

SE: Orthostatic hypotension, reflex tachy

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14
Q

A1 selective adrenergic antagonist used as TOC for BPH

A

Prazosin

SimD: Doxazosin, TERAZOSIN, TAMSULOSIN, Silodosin

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15
Q

A1 selective adrenergic antagonist used as Tx for BPH which is the most SELECTIVE to prostate smooth muscle

A

Tamsulosin

16
Q

Pharmacologic advantage of alpha1 selectivity

A

Reflex tachycardia is less common and less severe

17
Q

Beta nonselective sympathomimmetic/agonist which sounds like a Beta blocker

A

Isoproterenol

I SOrry! Akala ko Beta blocker ka!

18
Q

Beta nonselective adrenergic antagonist used as TOC for angina prophylaxis and hypertension

A

Propanolol

SimD: pindolol, timolol, labetalol, carvedilol

19
Q

Beta nonselective adrenergic antagonist that can be used on hypertensive asthmatic patients bec it is less likely to cause bronchospasm

Intrinsic Sympathomimmetic Activity

A

Pindolol

Beta1 selective adrenergic antagonist:
Acetabulol

ISA PA! Isa pang chicken joy!
Int. Sympatho. Act. Pindolol Acetabulol

20
Q

Beta nonselective adrenergic antagonist that has a combined alpha and beta blockade

A

Carvedilol and LABetalol

21
Q

Beta nonselective adrenergic antagonist that is useful in glaucoma patients bec unlike other beta blockers, they lack local anesthetic activity

A

Timolol

Beta1 selective adrenergic antagonist:
Betaxolol

22
Q

Beta nonselective adrenergic antagonist that has the longest half-life

A

NADOlol

NAsa DOlo

23
Q

Beta1 selective adrenergic antagonist used for angina, HPN, HF and SVT withless chance of bronchospasm

A

Atenolol
SimD: Betaxolol, Esmolol, Acetabulol, Metoprolol

SVT: Esmolol ONLY

24
Q

Beta1 selective adrenergic antagonist used for SVT

A

Esmolol

25
Q

Beta1 selective adrenergic antagonist witthe shortest half-life

A

Esmolol

26
Q

Carbonic anhydrase inhibitor commonly used for glaucoma

A

Acetazolamide

MOA: dec secretion of aqueous humor from the ciliary epithelium

27
Q

Target BP for antihypertensive patients

A

No comorbids <130/80

28
Q

Thiazide diuretic used as TOC/first line Tx for Stage 1 hypertension

Acts on DCT

A

Hydrochlorothiazide
SimD: Chlorthalidone, Indapamide, Metolazone

SE: hypokalemic metabolic alkalosis, dilutional hyponatremia, potassium wasting, hyperglycemia, hyperlipidemia, hyperuricemia

29
Q

Loop diuretic used for HF, pulmonary edema, HPN and ARF

Acts on THICK ASCENDING LIMB OF LOOP OF HENLE

A

Furosemide
SimD: Bumetanide, Torsemide, Ethacrynic acid

Low Ca, Low Mg

30
Q

Time it takes for Furosemide to take effect, expect UO

A

6 hours

Brand Name: LaSIX

31
Q

CNS sympathetic outflow blocker used for hypertension with known AE of REBOUND HYPERTENSION

A

Clonidine

Treat REBOUND HPN with Phentolamine

32
Q

Alpha2 selective sympathomimmetic and CNS sympathetic outflow blocker used as TOC for preeclampsia

A

Methyldopa

SE: hemolytic anemia with positive Coomb’s test

Pharmacology (23 decks)

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