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Pharmacology > Basics > Flashcards

Basics Flashcards

0
Q

PharmacoDynaMics

A

Drugs to Man

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1
Q

PharmacoKineTics

A

Katawan to Tableta

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2
Q

Inhibits Vitamin K clotting factors synthesis 10, 9, 7, 2 (1972)
Antidote: Acute - FFP, Chronic - Vitamin K

A

Warfarin

Monitor PT/INR

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3
Q

Activates anti-thrombin III

Antidote: Protamine Sulfate

A

Heparin

Monitor aPTT

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4
Q

Safest site at the buttocks for IM drug administration

A

Superolateral

Superomedial - may result to gluteus medius gait
Inferomedial - Sciatica

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5
Q

Rectal route with first-pass effect

A

Superior Rectal Vein: drains to IMV which then drains to Portal v.

Middle rectal v. - IIV to IVC
Inferior rectal v. - IPV to IIV to IVC

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6
Q

Drugs with zero-order elimination kinetics?

A 
WHAT PET
Warfarin
Heparin
Aspirin
Tolbutamide
Phenytoin
Ethanol
Theophyline
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7
Q

Creatinine Clearance formula

A

((140-age) x weight in kg) / (72 x serum Crea in mg/dL)

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8
Q

Drug metabolism

Phase I reactions

A 
HORDe of Phase I
Hydration
Oxidation
Reduction
Deamination
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9
Q

Phase II reactions

A 
Glucuronidation
Acetylation
Conjugation
Sulfation
Methylation
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10
Q

Cytochrome P450 inducers

A 
ETHel Booba takes PHEN-Phen and RIFuses GReasy CARB Shakes
Ethanol
Barbiturates
Phenytoin
Rifampicin
Griseofulvin
Carbamazepine
St. John's Wort / Smoking
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11
Q

Cytochrome P450 inhibitors

A 
Inhibitors Stop Cyber Kids from Eating GRApefruit QV
Isoniazid
Sulfonamides
Cimetidine
Ketoconazole
Erythromycin
Grapefruit juice
Ritonavir
Amiodarone
Quinidine
Valproic acid
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12
Q

FDA Drug categories

A

Classes:
A - safe to pregnant women and animals
B - no studies in pregnant women, unsafe in pregnant animals
C - no studies in pregnant women, no studies in pregnant animals (Benefits outweigh risks)
D - unsafe in pregnant women, unsafe in pregnant animals (for drugs needed in life-threatening conditions)
X - contraindicated in women who are or may become pregnant (Risks outweigh benefits)

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13
Q

Warfarin AE on pregnant women

A

1st tri chondrodysplasia
2nd tri CNS malformations
3rd tri bleeding diatheses

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14
Q

New drug application

A

Phases:
I - eval of pharmacoKineTics in normal human volunteers 25-50
II - eval of drugs in moderate no. Of patients with target dse (single blind or double blind)
III - many patients and many clinicians 1000-5000 (double blind), compare with older therapy, discover toxicities
IV - postmarketing surveillance

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15
Q

Parasympathetic ANS spinal roots

A

Cervical 10, 9, 7, 3 (1973)
Sacral segments of SC

PLASA
Para ANS, Long preganglionic, Acetylcholine, Short postganglionic, Acetylcholine

16
Q

Sympathetic ANS

A

Paravertebral ganglions along SC
T1-T12
L1-L5

Pharmacology (23 decks)

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