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Pharmacology > Antiarrhythmic Drugs > Flashcards

Antiarrhythmic Drugs Flashcards

0
Q

Difference between automaticity and conduction

A

Automaticity - origin of pacemaker activity (impulse) - should be SA NODE

Conduction - defined path of an impulse

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1
Q

Singh-Vaughan Williams Classification

A 
Classes:
I: sodium channel blockers - UPSTROKE
II: beta adrenoceptor blocker
III: potassium channel blockers - REPOLARIZATION
IV: calcium channel blockers - PLATEAU
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2
Q

What is Torsades de pointes?

A

Prolonged QT interval with variable shape of AP

ECG finding: POLYMORPHIC VENTRIC TACHY

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3
Q

Subgroups in CLASS 1 antiarrhythmic drugs

A

Group
1A prolong AP duration
1B shorten AP duration
1C no effect on AP duration

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4
Q

MOA of group 1A antiarrhythmic drugs

A

Slow or block conduction in ischemic and depolarized cells
Slow or abolish abnormal pacemakers

Depress tis. Frequently depolarizing
Depress tis. that relatively depolarizes during rest

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5
Q

Most commonly used antiarrhythmic drug with group 1A activity

A

Amiodarone

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6
Q

Class 1A antiarrhythmic used for arrhythmias esp after MI but causes LUPUS-LIKE syndrome (DRUG-INDUCED LUPUS)

A

Procainamide

Hyperkalemia exacerbates cardiac toxicity

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7
Q

Class 1A antiarrhythmic used for arrhythmias that causes cinchonism (headache vertigo and tinnitus), arrhythmia (Torsades) and ITP

A

Quinidine

Reduces clearance of digoxin

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8
Q

Class 1A antiarrhythmics

A

1 Am the QUeen who PROclaimed DISO PYRAMID

QUinidine
PROcainamide
DISOPYRAMIDe

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9
Q

Treatment of Class 1A antiarrhythmic overdose

A

Sodium lactose for arrhythmia

Pressor sympathomimmetic for hypotension

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10
Q

Class 1B Antiarrhythmics

1B Is Best postMI

A

MEXican Taco from LIly
MEXiletine
Tocainide
LIdocaine

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11
Q

What are the drugs that can cause agranulocytosis?

A 
Agranulocytosis CCCAAPPIT!!!
Clozapine
Co-trimoxazole
Colchicine
Aminopyrine
Phenylbutazone
PTU
Indomethacin
Tocainide
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12
Q

Least cardiotoxic among conventional antiarrhythmics

A

Lidocaine

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13
Q

DOC for ventricukar arrhythmias postMI and digoxin-induced arrhythmias

A

Lidocaine
SimD: Mexiletine, Tocainamide, Phenytoin*

SE: CNS stimulation, CV depression, arrhythmias
IMPT SE: Agranulicytosis for Tocainamide

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14
Q

Class 1C antiarrhythmic used for REFRACTORY ARRHYTHMIAS that is known to cause MORE arrhythmias and BRUGADA SYNDROME

A

Flecainide
SimD: Propafenone, Encainide, Moricizine

Ch1Cken ay Pagkain For Enrico

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15
Q

Class 1B antiarrhythmic drugs

1C Is Contraindicated postMI

A 
Ch1Cken ay Pagkain For Enrico
Propafenone
Fleicanide
Encainide
Moricizine
16
Q

Antiarrhythmic drugs used in WPW syndrome

A

Procainamide and Amiodarone

Both with class 1A activity

17
Q

Class 2 antiarrhythmic that has an effect on phase 4 is manifested in ECG as

A

Prolonged PR Interval

Due to beta-adrenoceptor blockade and reduction in cAMP

Group 2 effects shown also by SOTALOL and AMIODARONE

18
Q

Class 2 antiarrhythmic drugs used as postMI prophylaxis against sudden death, and used as well in thyrotoxicosis

A

Propranolol, metoprolol, timolol

SE: bronchospasm, etc.

19
Q

Beta blcker with class 3 antiarrhythmic property

A

Sotalol

20
Q

Beta blocker with the shortest halflife which is used in ACUTE PERIOPERATIVE AND THYROTOXIC ARRHYTHMIAS and SVT

A

ESMOLol

SMOL - maliit na halflife

21
Q

Class 3 antiarrhythmic drugs

A

Seen as inc in QT Interval on ECG

22
Q

Class 3 antiarrhythmic drug used for AF as Tx and prophylaxis

A

Dofelitide
SimD: Ibutilide

dOFelitide for AF

SE: Torsades de Pointes

23
Q

Only class 3 antiarrhythmic drug that is a beta blocker also used for SVT, ventric arrhyth and AF

A

Sotalol

24
Q

Class 3 antiarrhythmic drugs that is most efficacious of all antiarrhythmics

A

Amiodarone
SimD: Dronedarone

SE: Pulmonary fibrosis, Opthalmologic sx (corneal deposits), Thyroid dysfunction

25
Q

Class 3 antiarrhythmic drugs

Prolonds AP duration by delaying repolarization, manifested as inc QT interval on ECG

A 
AIDS
Amiodarone
Ibutilide
Dofetilide
Sotalol
26
Q

Why are Dihydropyridine CCBs not useful as an antiarrhythmic drug?

A

It evokes compensatory discharge which promotes more arrhythmias

PROARRHYTHMIC THAN ANTIARRHYTHMIC

27
Q

Class 4 antiarrhythmic drugs

Dec AV conduction velocity and ERP

ECG: PR interval consistently increased

A

Verapamil, Diltiazem

28
Q

Miscellaneous antiarrhythmic used as DOC for PAROXYSMAL SVT

A

Adenosine

SE: flushing

Pharmacology (23 decks)

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