Asthma Drugs

Question 1

Short-acting Beta2 selective agonist which is the DOC for acute asthma attacks

Answer 1

Salbutamol/Albuterol

SimD: Terbutaline, Levalbuterolm, Metaproterenol, Pirbuterol, Procaterol, Fenoterol

Question 2

Long-acting Beta2 selective agonist used as asthma prophylaxis (NOT for acute relief)

Answer 2

Salmeterol

SimD: Formoterol, Cleneterol, Bambuterol

Question 3

Muscarinic receptor antagonist used for asthma and COPD

AE: dry mouth

Answer 3

Ipatropium

SimD: Tiotropium

Question 4

Methylxanthine used as asthma prophylaxis against nocturnal attacks, known to have NARROW therapeutic window

AE: insomnia, seizures and tremors

Answer 4

Theophylline

SimD: Aminophylline, Pentoxyfilline

Antidote for overdosage: Beta-blockers

Question 5

Mast cell stabilizer used as asthma prophylaxis and for ophthalmologic, nasopharyngeal and GI allergies

Answer 5

Cromolyn

SimD: Nedocromil, Lodoxamide

Question 6

Corticosteroid which is the DOC for asthma prophylaxis, also used for COPD and AR

AE: oral candidiasis, mild growth retardation

Answer 6

Fluticasone

IV Hydrocortisone usedin severe refractory asthma (STATUS ASTHMATICUS)
Ciclesonide - lowest systemic steroid toxicity

Question 7

Leukotriene synthesis (5-lipoxygenase) inhibitor used as asthma prophylaxis and for exercise-, antigen- and aspirin-induced bronchospasm/asthma

AE: Flulike syndrome, hepatitis

Answer 7

Zileuton

NO bronchodilator action

Question 8

Leukotriene antagonist used as asthma prophylaxis and for exercise-, antigen- and aspirin-induced bronchospasm/asthma

GI upset, Insomnia, CHURG-STRAUSS syndrome

Answer 8

Montelukast

NO bronchodilator action

Question 9

Anti-IgE antibody used as prophylaxis for severe, refractory asthma not responsive to other drugs

AE: EXTREMELY EXPENSIVE, longterm toxcity-unknown

Answer 9

Omalizumab