Cholinomimmetics

Question 0

Direct-acting cholinomimmetic for glaucoma and Sjogren’s syndrome

Answer 0

Pilocarpine

Question 1

Direct-acting cholinomimmetic for (B)ladder and (B)owel atony

Answer 1

(B)etanechol

Used in post-surgery or SC injury

Question 2

Triad of Sjogren’s syndrome

Answer 2

Xerostomia - dry mouth
Xerophthalmia - dry eyes
Rheumatoid arthritis (RA)

Question 3

Direct-acting cholinomimmetic, nicotinic for smoking cessation

Answer 3

Nicotine
SimD: Varenicline

SE: convulsions, paralysis, coma

Question 4

Indirect-acting cholinomimmetic for Myasthenia gravis DIAGNOSIS - Tensilon test

Answer 4

Edrophonium

Very short acting upon IV admin

Question 5

Differentiates Myasthenic VS Cholinergic crisis

Answer 5

Edrophonium

Myasthenic crisis - worsening of sx d/t undermedication -> improves wd Edrophonium

Cholinergic crisis - excessive activation of cholinoreceptors -> weakens wd Edrophonium

Question 6

Indirect-acting cholinomimmetic for Myasthenia gravis TREATMENT

Answer 6

Neostigmine
SimD: Pyridostigmine, Physostigmine

Also for Olgivie syndrome (pseudoobstruction of gut, no mech obst seen)
For glaucoma (Physostigmine only)

Question 7

Indirect-acting cholinomimmetic for Alzheimer’s disease

Answer 7

Rivastigmine (rivaZtigmine for alZheimer)

SimD: Galantamine, DONEPEZIL, Tacrine