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Pharmacology > ANTI-VIRALS ⛑ > Flashcards

ANTI-VIRALS ⛑ Flashcards

1
Q

Penetration/uncoating

A

AMANTIDINE

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2
Q

Viral DNA polymerase

A

ACYCLOVIR

FORSCARNET

GANCYCLOVIR

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3
Q

Viral RNA polymerase

A

Foscarnet or Ribavirin

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4
Q

Reverse transcriptase

A

AZT

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5
Q

Neuraminidase

A

Oseltamivir

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6
Q

Guanine analog

DOC for CMV retinitis, pneumonia and esophagitis

A

Gancyclovir

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7
Q

Phospahte analog

A

Foscarnet

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8
Q

DOC for CMV retinitis

A

Foscarnet

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9
Q

Anti-virals for Respiratory Viruses

A

Amantadine

Rimantadine

Ribavirin

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10
Q

MOA: inhibit viral uncoating

Used as prophylaxis for Influenza A

PARKINSONISM’S DISEASE

A

Amantadine and rimantadine

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11
Q

For RSV bronchiolitis and pneumonia

A

Ribavirin

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12
Q

Influenza A, B and Lassa fever, Hepatitis C

A

Ribavirin

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13
Q

Two types of Ribavirin:

Reverse transcriptase inhibitors

Protease inhibitors

A

Ribavirin

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14
Q

Thymidine analog

A

Zidovudine or AZT

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15
Q

Adenosine analog

A

Didanosine or DDL

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16
Q

Cytosine analog

A

Zalcitabine or ddC

17
Q

Thymine analog

A

Stavudine or d4T

18
Q

Hepa B

A

Lamivudine

19
Q

Protease inhibitors

Adverse effects: diarrhea, nausea and vomiting

A

Saquinavir, Ritonavir, Indinavir, Nelfinavir

20
Q

Drugs to prevent infection in HIV

A

Clarithromycin

Azithromycin

21
Q

> 5mm (TB)

A

Isoniazid

Rifampicin

22
Q

Drugs for HERPES

A

Foscarnet

Ganciclovir

Idoxuridine

Vidarabine

Acyclovir

“For herpes, GIV Acyclovir”

23
Q

Most anti metabolites

Pro-drugs

A

Anti-virals

24
Q

RNA virus REPLICATIVE CYCLE

A

Hemagglutinin

Uncoating

Replicatiom

Budding or release

25
Q

Transition state analog of sialic acid

A

Oseltamivir

26
Q

Active against influenza A and B

A

Oseltamivir

27
Q

MOA: reversible inhibition of viral neuraminidases producing viral aggregation on the cell surface preventing release and spread of viral progeny

A

Oseltamivir

28
Q

MOA of Oseltamivir involves in bloxking of viral

A

Release

29
Q

Guanine analog

A

Acyclovir

Ganciclovir

30
Q

For HSV 1 and 2 and Varicella

A

Acyclovir

31
Q

Adverse effects of Oseltamivir

A

Crytalluria and neurotoxicity

32
Q

Its not hematotoxic

Its nephrotoxic

A

Acyclovir

33
Q

Acts as a chain terminator

A

Acyclovir

Pharmacology (23 decks)

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