ANTI-VIRALS ⛑ Flashcards
Penetration/uncoating
AMANTIDINE
Viral DNA polymerase
ACYCLOVIR
FORSCARNET
GANCYCLOVIR
Viral RNA polymerase
Foscarnet or Ribavirin
Reverse transcriptase
AZT
Neuraminidase
Oseltamivir
Guanine analog
DOC for CMV retinitis, pneumonia and esophagitis
Gancyclovir
Phospahte analog
Foscarnet
DOC for CMV retinitis
Foscarnet
Anti-virals for Respiratory Viruses
Amantadine
Rimantadine
Ribavirin
MOA: inhibit viral uncoating
Used as prophylaxis for Influenza A
PARKINSONISM’S DISEASE
Amantadine and rimantadine
For RSV bronchiolitis and pneumonia
Ribavirin
Influenza A, B and Lassa fever, Hepatitis C
Ribavirin
Two types of Ribavirin:
Reverse transcriptase inhibitors
Protease inhibitors
Ribavirin
Thymidine analog
Zidovudine or AZT
Adenosine analog
Didanosine or DDL
Cytosine analog
Zalcitabine or ddC
Thymine analog
Stavudine or d4T
Hepa B
Lamivudine
Protease inhibitors
Adverse effects: diarrhea, nausea and vomiting
Saquinavir, Ritonavir, Indinavir, Nelfinavir
Drugs to prevent infection in HIV
Clarithromycin
Azithromycin
> 5mm (TB)
Isoniazid
Rifampicin
Drugs for HERPES
Foscarnet
Ganciclovir
Idoxuridine
Vidarabine
Acyclovir
“For herpes, GIV Acyclovir”
Most anti metabolites
Pro-drugs
Anti-virals
RNA virus REPLICATIVE CYCLE
Hemagglutinin
Uncoating
Replicatiom
Budding or release
Transition state analog of sialic acid
Oseltamivir
Active against influenza A and B
Oseltamivir
MOA: reversible inhibition of viral neuraminidases producing viral aggregation on the cell surface preventing release and spread of viral progeny
Oseltamivir
MOA of Oseltamivir involves in bloxking of viral
Release
Guanine analog
Acyclovir
Ganciclovir
For HSV 1 and 2 and Varicella
Acyclovir
Adverse effects of Oseltamivir
Crytalluria and neurotoxicity
Its not hematotoxic
Its nephrotoxic
Acyclovir
Acts as a chain terminator
Acyclovir
