Sympathomimetic Agents Flashcards
Epinephrine effects?
1) a1 (+++)
2) a2 (+++)
3) B1 (++++)
4) B2 (++++)
NE effects?
1) a1 (++++)
2) a2 (++++)
3) B1 (++)
Isoproterenol effects?
B1 = B2
Dopamine effects?
1) High dose: a1 = a2
2) Medium dose: B1 > B2
3) Low dose: D1
Dobutamine effects?
B1 big time (everything else minimal, no D1 effect)
Phenylephrine effects?
a1 > a2
Albuterol, salmeterol, terbutaline effects?
B2 > B1
Ritodrine effects?
B2 only
Indirect sympathomimetics?
1) Amphetamine
2) Ephedrine
3) Cocaine
Uses for epi?
Anaphylaxis, open angle glaucoma, asthma, hypotension
Uses for NE?
Hypotension (but low renal perfusion), 1st line for septic shock
Uses for isoproterenol?
1) Torsade de pointes (tachycardia decreases QT interval)
2) Bradyarrhythmias (but can worsen ischemia)
Uses for dopamine?
1) Shock (RENAL PERFUSION)
2) Heart failure (inotropic and chronotropic)
Uses for dobutamine?
1) Heart failure (inotropic and chronotropic)
2) Cardiac stress testing
3) Cardiogenic shock
3) Increases contractility without vasodilation (no effect on BP)
Uses for phenylephrine?
1) Hypotension (vasoconstrictor)
2) Ocular procedures (mydriatic)
3) Rhinitis (decongestant)
Uses for metaproterenol and albuterol?
Acute asthma
Uses for salmeterol?
Long term asthma or COPD control
Uses for terbutaline?
Reduce premature uterine contractions (tocolytic)
Uses for ritodrine?
Reduces premature uterine contractions (tocolytic)
MOA of amphetamines and ephedrine?
Indirect general agonist that releases stored catecholamines
MOA of cocaine?
Indirect general agonist that inhibits reuptake
Uses for amphetamines?
Narcolepsy, obesity, ADD
Uses for ephedrine?
Nasal decongestion, urinary incontinence, hypotension
Uses for cocaine?
Causes vasoconstriction and local anesthesia
What do you NOT give to someone with cocaine OD?
B-blockers–causes unopposed a1 activation and extreme HTN)
