Sympathomimetic Agents

Question 1

Epinephrine effects?

Answer 1

1) a1 (+++)
2) a2 (+++)
3) B1 (++++)
4) B2 (++++)

Question 2

NE effects?

Answer 2

1) a1 (++++)
2) a2 (++++)
3) B1 (++)

Question 3

Isoproterenol effects?

Answer 3

B1 = B2

Question 4

Dopamine effects?

Answer 4

1) High dose: a1 = a2
2) Medium dose: B1 > B2
3) Low dose: D1

Question 5

Dobutamine effects?

Answer 5

B1 big time (everything else minimal, no D1 effect)

Question 6

Phenylephrine effects?

Answer 6

a1 > a2

Question 7

Albuterol, salmeterol, terbutaline effects?

Answer 7

B2 > B1

Question 8

Ritodrine effects?

Answer 8

B2 only

Question 9

Indirect sympathomimetics?

Answer 9

1) Amphetamine
2) Ephedrine
3) Cocaine

Question 10

Uses for epi?

Answer 10

Anaphylaxis, open angle glaucoma, asthma, hypotension

Question 11

Uses for NE?

Answer 11

Hypotension (but low renal perfusion), 1st line for septic shock

Question 12

Uses for isoproterenol?

Answer 12

1) Torsade de pointes (tachycardia decreases QT interval)

2) Bradyarrhythmias (but can worsen ischemia)

Question 13

Uses for dopamine?

Answer 13

1) Shock (RENAL PERFUSION)

2) Heart failure (inotropic and chronotropic)

Question 14

Uses for dobutamine?

Answer 14

1) Heart failure (inotropic and chronotropic)
2) Cardiac stress testing
3) Cardiogenic shock
3) Increases contractility without vasodilation (no effect on BP)

Question 15

Uses for phenylephrine?

Answer 15

1) Hypotension (vasoconstrictor)
2) Ocular procedures (mydriatic)
3) Rhinitis (decongestant)

Question 16

Uses for metaproterenol and albuterol?

Answer 16

Acute asthma

Question 17

Uses for salmeterol?

Answer 17

Long term asthma or COPD control

Question 18

Uses for terbutaline?

Answer 18

Reduce premature uterine contractions (tocolytic)

Question 19

Uses for ritodrine?

Answer 19

Reduces premature uterine contractions (tocolytic)

Question 20

MOA of amphetamines and ephedrine?

Answer 20

Indirect general agonist that releases stored catecholamines

Question 21

MOA of cocaine?

Answer 21

Indirect general agonist that inhibits reuptake

Question 22

Uses for amphetamines?

Answer 22

Narcolepsy, obesity, ADD

Question 23

Uses for ephedrine?

Answer 23

Nasal decongestion, urinary incontinence, hypotension

Question 24

Uses for cocaine?

Answer 24

Causes vasoconstriction and local anesthesia

Question 25

What do you NOT give to someone with cocaine OD?

Answer 25

B-blockers–causes unopposed a1 activation and extreme HTN)