Antifungals

Question 1

Causes accumulation of squalene that inhibits ergosterol synthesis?

Answer 1

Terbinafine

Question 2

Causes accumulation of lanosterol that inhibits ergosterol synthesis?

Answer 2

Azoles

Question 3

Tx for cryptococcal meningitis?

Answer 3

Amphotericin B + flucytosine

Question 4

Given intrathecally for fungal meningitis?

Answer 4

Amphotericin B–bc it does not cross BBB

Question 5

Wide-spectrum used for systemic mycoses?

Answer 5

Amphotericin B, itraconazole

Question 6

May causes arrhythmias due to changes in K and Mg levels?

Answer 6

Amphotericin B

Question 7

Too toxic for systemic use, only used for oral candidiasis, diaper rash and vaginal candidiasis?

Answer 7

Nystatin

Question 8

Used for candiduria due to it being metabolized by kidneys?

Answer 8

Fluconazole

Question 9

Used for chronic suppression of cryptococcal meningitis in AIDS?

Answer 9

Fluconazole–bc i can cross BBB

Question 10

Inhibits ergosterol synthesis by inhibiting P450?

Answer 10

Azoles

Question 11

Azoles used for topical fungal infections?

Answer 11

Clotrimazole and micronazole (too toxic for systemic use)

Question 12

Inhibits testosterone synthesis causing gynecomastia?

Answer 12

Ketoconazole

Question 13

Tx for Cushing’s?

Answer 13

Ketoconazole

Question 14

Converted to active form by cytosine deaminase?

Answer 14

Flucytosine

Question 15

May cause pancytopenia (bone marrow suppression)?

Answer 15

Flucytosine

Question 16

Inhibits synthesis of B-glucan?

Answer 16

Caspsofungin

Question 17

Tx for invasive aspergillosis?

Answer 17

Caspofungin

Question 18

Use for fungal nail infections?

Answer 18

Terbinafine

Question 19

Drug may cause abnormal LFTs?

Answer 19

Terbinafine

Question 20

Disrupts mitosis in keratin-containing tissues?

Answer 20

Griseofulvin

Question 21

Only anti-fungal that is teratogenic and carcinogenic?

Answer 21

Griseofulvin

Question 22

Induces CYP450?

Answer 22

Griseofulvin