Lipid Lowering Drugs

Question 1

Best at lowering LDL?

Answer 1

Statins

Question 2

Best at raising HDL?

Answer 2

Niacin

Question 3

Best at lowering TGs?

Answer 3

Fibrates

Question 4

2nd line choice for lowering LDL?

Answer 4

Cholesterol absorption blockers (ezetimibe)

Question 5

2 drugs that are hepatotoxic?

Answer 5

Statins and fibrates (increases LFTs)

Question 6

2 drugs that cause cholesterol gallstones?

Answer 6

Fibrates and bile acid resins

Question 7

2 drugs that causes myositis?

Answer 7

Statins and fibrates

Question 8

Exacerbates gout by increasing uric acid?

Answer 8

Niacin

Question 9

Decreases gallstones?

Answer 9

Cholesterol absorption blockers (ezetimibe)

Question 10

Cause of red facial flushing with niacin use?

Answer 10

Increase in prostaglandins

Question 11

How to prevent flushing?

Answer 11

Aspirin

Question 12

2nd line choice for lowering TGs?

Answer 12

Niacin

Question 13

May cause hyperglycemia (acanthosis nigricans)?

Answer 13

Niacin

Question 14

Causes GI discomfort and bad taste?

Answer 14

Bile acid resins

Question 15

MOA of niacin?

Answer 15

Inhibits lipolysis in adipose tissue, reduces hepatic VLDL secretion into circulation

Question 16

MOA of bile acid resins?

Answer 16

Prevents intestinal reabsorption of bile acids–>liver must use cholesterol to make more

Question 17

MOA of fibrates?

Answer 17

Upregulates LPL via stimulation of PPAR-a, which makes HDL cholesterol apolipoproteins; increasing LPL causes TG lysis

Question 18

Why are bile acid resins given with statins?

Answer 18

BARs increase cholesterol synthesis in liver

Question 19

What drug INCREASES triglycerides?

Answer 19

Bile acid resins (NOT GOOD)