Drug Reactions

Question 1

Coronary vasospasm?

Answer 1

Cocaine, ergot alkaloids, sumatriptan (CEASe)

Question 2

Cutaneous flushing?

Answer 2

Vancomycin, Adenosine, Niacin, CCBs (VANC)

Question 3

Dilated cardiomyopathy?

Answer 3

Doxorubicin (Adriamycin), daunorubicin (DAD)

Question 4

Torsades de pointes?

Answer 4

Class III (sotalol) and class IA (quinidine) antiarrhythmics

Question 5

Agranulocytosis?

Answer 5

Clozapine, Carbamazepine, Colchicine, PTU, Methimazole, Dapsone
Agranulocytosis Could Certainly Cause Pretty Major Damage

Question 6

Aplastic anemia?

Answer 6

Chloramphenicol, benzene, NSAIDs, PTU, methimazole

Question 7

Direct Coombs-positive hemolytic anemia?

Answer 7

Methyldopa, penicillin

Question 8

Gray babby syndrome?

Answer 8

Chloramphenicol

Question 9

Hemolysis in G6PD deficiency?

Answer 9

INH, Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin (Hemolysis IS PAIN)

Question 10

Megaloblastic anemia?

Answer 10

Phenytoin, Methotrexate, Sulfas (PMS)

Question 11

Thrombotic complications?

Answer 11

OCPs (e.g. estrogens)

Question 12

Cough?

Answer 12

ACEIs

Question 13

Pulmonary fibrosis?

Answer 13

BLeomycin, Amiodarone, Busulfan (BLAB)

Question 14

Acute cholestatic hepatitis and jaundice?

Answer 14

Erythromycin

Question 15

Focal to massive hepatic necrosis?

Answer 15

Halothane, Amanita phalloides, Valproic acid, Acetaminophen (Liver HAVAc)

Question 16

Hepatitis?

Answer 16

INH

Question 17

Pseudomembranous colitis?

Answer 17

Clindamycin, ampicillin, cephalosporins

Question 18

Adrenocortical insufficiency?

Answer 18

Abrupt glucocorticoid withdrawal (HPA suppression)

Question 19

Gynecomastia?

Answer 19

Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole (Some Drugs Create Awkward Knockers)

Question 20

Hot flashes?

Answer 20

Tamoxifen, clomiphene

Question 21

Hyperglycemia?

Answer 21

Niacin, tacrolimus, protease inhibitors, HCTZ, corticosteroids

Question 22

Hypothyroidism?

Answer 22

Lithium, amiodarone, sulfonamides

Question 23

Fat redistribution?

Answer 23

Glucocorticoids, protease inhibitors

Question 24

Gingival hyperplasia?

Answer 24

Phenytoin, verapamil

Question 25

Gout?

Answer 25

Furosemide, thiazides, niacin, cyclosporine

Question 26

Myopathies?

Answer 26

Fibrates, Niacin, Colchicine, Hydroxychloroquine, IFN-a, Penicillamine, Statins, Glucocorticoids (Fish N CHIPS Give you myopathies)

Question 27

Osteoporosis?

Answer 27

Corticosteroids, heparin

Question 28

Photosensitivity?

Answer 28

Sulfonamides, Amiodarone, Tetracycline (SAT for a photo)

Question 29

Rash (Stevens-Johnson)

Answer 29

Penicillin, Ethosuxamide, Carbamazepine, Sulfas, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital (bad rash after a PEC SLAPP)

Question 30

SLE-like syndrome?

Answer 30

Hydralazine, INH, Procainamide, Phenytoin (HIPP)

Question 31

Teeth (kids)?

Answer 31

Tetracyclines

Question 32

Tendonitis, tendon rupture, and cartilage damage?

Answer 32

Fluoroquinolones

Question 33

DI?

Answer 33

Lithium, demeclocycline

Question 34

Fanconi’s?

Answer 34

Expired tetracycline

Question 35

Hemorrhagic cystitis?

Answer 35

Cyclophosphamide, ifosfamide

Question 36

Interstitial nephritis?

Answer 36

Methicillin, NSAIDs, furosemide

Question 37

SIADH?

Answer 37

Carbamazepine, cyclophosphamide

Question 38

Cinchonism?

Answer 38

Quinidine, quinine

Question 39

Parkinson-like syndrome?

Answer 39

Antipsychotics, reserpine, metoclopramide

Question 40

Seizures?

Answer 40

INH, Buproprion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide (I BITE My tongue)

Question 41

Antimuscarinic?

Answer 41

Atropine, TCAs, H1-blockers, neuroleptics

Question 42

Disulfiram-like reaction?

Answer 42

Metronidazole, certain cephalosporins, procarbazine, 1st-generation sulfonylureas

Question 43

Nephrotoxicity and ototoxicity?

Answer 43

Aminoglycosides, vancomycin, loop diuretics, cisplatin