Muscarinic Antagonists

Question 1

Which drugs work on the eye?

Answer 1

1) Atropine
2) Homatropine
3) Tropicamide

Question 2

Which drugs act on the CNS?

Answer 2

1) Benztropine

2) Scopolamine

Question 3

Which drugs act on the respiratory system?

Answer 3

Ipratropium and tiotropium

Question 4

Which drug works on the GU system?

Answer 4

Oxybutynin

Question 5

Which drug acts on both the GI and respiratory systems?

Answer 5

Glycopyrrolate

Question 6

Which drug is contraindicated in glaucoma?

Answer 6

Atropine!!!

Question 7

Uses for atropine?

Answer 7

Bradycardia and ophthalmic procedures

Question 8

Effects of atropine?

Answer 8

1) Pupil dilation and cycloplegia
2) Decreases airway secretions
3) Decreases gastric acid secretion
4) Decreases gut motility
5) Decreases urgency in cystitis

Question 9

What systems are NOT effected by atropine?

Answer 9

Skeletal muscles and CNS (due to being mediated by nicotinic receptors)

Question 10

Use for benztropine?

Answer 10

Parkinson’s

Question 11

Use for scopolamine?

Answer 11

Motion sickness

Question 12

Uses for ipratropium?

Answer 12

COPD and asthma

Question 13

Uses for oxybutynin?

Answer 13

Reduce urgency in mild cystitis and reduce bladder spasms, urge incontinence, overactive bladder

Question 14

Uses for glycopyrrolate?

Answer 14

1) Parenteral: preop use to reduce airway secretions

2) Oral: drooling, peptic ulcers

Question 15

What can atropine cause in 3 age groups?

Answer 15

1) Infants–hyperthermia
2) Men with BPH–urinary retention
3) Elderly–acute-angle glaucoma due to mydriasis

Question 16

What drugs have antimuscarinic effects?

Answer 16

1) Atropine
2) TCAs
3) H1 blockers
4) Neuroleptics
5) Antiparkinson drugs