Glaucoma Drugs

Question 1

Alpha-agonists used for glaucoma?

Answer 1

Epinephrine, brimonidine

Question 2

B-blockers used for glaucoma?

Answer 2

Timolol, betaxolol, carteolol

Question 3

Diuretic used for glaucoma?

Answer 3

Acetazolamide

Question 4

Cholinemimetics used for glaucoma?

Answer 4

Direct–pilocarpine, carbachol; indirect–physostigmine, echothiophate

Question 5

Prostaglandin used for glaucoma?

Answer 5

Latanoprost (PGF2a)

Question 6

MOA of epinphrine?

Answer 6

Decreases aqueous humor synthesis via vasoconstriction

Question 7

MOA of brimonidine?

Answer 7

Decrease aqueous humor synthesis

Question 8

MOA of B-blockers?

Answer 8

Decrease aqueous humor secretion

Question 9

MOA of diuretics?

Answer 9

Decrease aqueous humor secretion via lowering HCO3- (by inhibiting carbonic anhydrase)

Question 10

MOA of cholinomimetics?

Answer 10

Increase outflow of aqueous humor via contraction of ciliary muscle and opening of trabecular meshwork

Question 11

What is used in emergencies?

Answer 11

Pilocarpine–very effective at opening meshwork into canal of Schlemm

Question 12

MOA of latanoprost?

Answer 12

Increase outflow of aqueous humor

Question 13

What drug is contraindicated in closed angle glaucoma?

Answer 13

Epinephrine

Question 14

Which drug may darken the color the iris (browning)?

Answer 14

Latanoprost

Question 15

Drugs that decrease aqueous humor SYNTHESIS?

Answer 15

1) Alpha agonist
2) B blockers
3) Acetazolamide

Question 16

Drugs that increase OUTFLOW?

Answer 16

1) Cholinomimetics

2) Latanoprost