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Pharmacology > sympathetic nervous system > Flashcards

sympathetic nervous system Flashcards

1
Q

alpha1 receptor effects

A
  • smooth muscle contraction
  • vasoconstriction
  • mydriasis
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2
Q

alpha2receptor effects

A
  • inhibition of neurotransmitter release
  • GI relaxation
  • inhibition of insulin release
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3
Q

beta1 receptor effects

A

cardiac effects - positive inotropic, chronotropic

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4
Q

beta2 receptor effects

A
  • vasodilation
  • bronchodilation
  • uterus relaxation
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5
Q

beta3 receptor effects

A

lipolysis in fat tissue

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6
Q

types of drugs acting on sympathethic nervous system

A
  • sympathomimetics

- sympathlytics

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7
Q

sympathomimetics cardiovascular effects

A
  • pos chronotropic
  • pos inotropic
  • vasconstriction
  • vasodilation
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8
Q

sympathomimetics GI effects

A
  • smooth muscle relaxation

- GI atony

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9
Q

sympathomimetics resp system

A

bronchodilation, decr bronchial secretion

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10
Q

sympathomimetics urinary bladder effects

A

incr sphincter constriction

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11
Q

sympathomimetics eye effects

A
  • mydriasis

- incr in aqueous humour production

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12
Q

nonspecific sympathomimetics

A
  • adrenaline
  • noradrenaline
  • dopamine
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13
Q

specific sympathomimetics

A
  • dobutamine

- isoproterenol

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14
Q

adrenaline indications

A
  • cardiac stop
  • severe bronchodilation
  • anaphylaxia
  • local vasoconstriction
  • incr in duration of local anaesthetics
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15
Q

adrenaline features

A
  • nonspecific
  • alpha receptors
  • cardiac effect
  • arrhytmogenic
  • blood pressure
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16
Q

adrenaline dose ca, fe

A

0.02mg/kg intratracheal IV

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17
Q

noradrenaline indication

A

hypotension

18
Q

noradrenaline features

A
  • non specific
  • cardiac effect
  • blood pressure is significantly increased
19
Q

dopamine low dose D1 receptors

A

kidney, 2-5microgram/kg

20
Q

dopamine medium dose beta1 receptors

A

heart 5-10microgram/kg

21
Q

dopamine high dose alpha1 receptors

A

10-20microgram/kg

22
Q

dobutamine indications

A

cardiogenic shock, IV infusion

23
Q

dobutamine features

A
  • mainly beta1 receptors

- cardiac effect

24
Q

isoproterenol features

A
  • only beta receptors

- heart and bronchi and muscle vessels

25
Q

beta2 agonists

A
  • clenbuterole
  • salbutamole
  • terbutaline
  • salmeterole
  • isoxsuprine
26
Q

effects on beta2 receptors

A
  • bronchodilation

- uterus relaxation

27
Q

beta2 agonists indications

A
  • horse RAO
  • feline asthma
  • bronchitis, bronchopneumonia
  • tracheal hypoplasia
  • tracheal collapse
28
Q

alpha adrenoceptor agonists

A
  • phenylephrine
  • xylometazoline
  • oxymetazoline
  • naphazoline
  • tetryzoline
  • phenylpropanolamine
  • ephedrine
  • amphetamine
29
Q

phenylephrine features

A
  • mainly alpha1 receptors - vasoconstriction
  • used rarely
  • local and systemic usage
30
Q

phenylephrine local usage

A

allergy, cold

31
Q

phenylephrine systemic usage

A

hypotension, shock

32
Q

xylometazoline, oxymetazoline, naphazoline, tetryzoline features

A
  • mainly alpha1 receptors - vasoconstriction

- local usage

33
Q

phenylpropanolamine features

A
  • mainly alpha1 receptors - urinary bladder sphincter constriction
  • per os usage
  • side effects
34
Q

ephedrine features

A
  • nonspecific, direct and indirect effects
  • tachyphylaxis
  • CNS
  • allergy, incontinence
35
Q

alpha2 agonists

A

xylazine, detomidine, medetomidine, romifidine

36
Q

types of sympatholytics

A
  • alpha adrenoceptor antagonists

- beta adrenoceptor antagonists

37
Q

types of alpha adrenoceptor antagonists

A
  • non specific alpha antagonists
  • alpha1 antagonists
  • alpha2 antagonists
38
Q

nonspecific alpha antagonists

A
  • phenoxybenzamine - long duration of action
  • phentolamine
  • tolazoline
39
Q

alpha1 antagonists

A

prazosine, doxasozine - urethra spincter relaxation

40
Q

alpha2 antagonists

A

atipamezole, yohimbine

41
Q

nonspecific beta antagonists

A

-propanolole
-timolole
side effects

42
Q

specific beta1 antagonists

A
  • metaprolole

- atenolole

Pharmacology (23 decks)

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