other anti-inflammatory Flashcards
JAK inhibitors indications
- rheumatoid arthritis
- crohns disease
- leukemias
- alopecia
oclacitinib indications
atopic dermatitis
common cause of atopic dermatitis
commonly from flea bites - saliva of fleas
JAK inhibitors pharmacological effects
- antiinflammatory
- antiallergic
- antipruritis
JAK inhibitors absorption
excellent per os absorption, 90%
JAK inhibitors absorption with food
no difference
JAK inhibitors metabolism
liver
JAK inhibitors interactions
no interactions with other drugs
JAK inhibitors side effects
no major, but sometimes causes vomiting
lokivetmab specificity
highly specific
other allergy mediated diseases
- atopic dermatitis
- cutanous food adverse reactions
- FAD
are antihistamines antagonists
no, theyre inverse agonists
the two forms of histamine receptors
active and inactive
antihistamines usage
- individual differences
- allergic diseases
- asthma, RAO
- anaphylactic reaction
how many generations of antihistamines
2
list 1st generation antihistamines groups
- ethylenediamines
- ethanolamines
- phenothiazines
- piperazines
- others - dimetinden, cyproheptadine
list 2nd generation antihistamines groups
loratadine, certirizine, levocetirizine
ethylenediamines
chloropyramine, chlorpheiramine
ethanolamines
diphenhydramine, dimenhydrinate
phenothiazines
promethazine
piperazines
hydroxyzine
side effects of 1st generation antihistamines
can decr appetite, cause sedation, sleepiness, decr co-ordination
safety of second generation
cannot cross blood brain barrier, v safe
antihistamines absorption
good oral absorption, Cmax 2-3hrs
2nd generation antihistamines distribution
ionised form and extensively albumin bound
antihistamines metabolism
liver-> CYP450 inducers
antihistamines side effects
- CNS depression
- cardiac toxicity
- anticholinergic effect
- appetite depression
