immunosuppression Flashcards
1
Q
three main immunosuppression indications
A
- autoimmune diseases
- hypersensitivity diseases
- transplantation
2
Q
immunosuppression drug groups
A
- antimetabolites
- alkylating agents
- glucocorticoids
- cytokine gene expression inhibitors
3
Q
antimetabolites types
A
- purine analogues
- pyrimidine analogues
- folic acid antagonists
4
Q
alkylating agents
A
cyclophosphamide
5
Q
cytokine gene expression inhibitors
A
calcineurin-inhibitors
6
Q
list of antimetabolites
A
- azathioprine
- mycophenolate mofetil
- methotrexate
7
Q
release azathioprine
A
slow release -> longer effect
8
Q
azathioprine admin route
A
Iv or oral
9
Q
mycophenolate mofetil is it a prodrug
A
yes
10
Q
mycophenolate specificity
A
expecially specific to T and B lymphocytes
11
Q
mycophenolate safety
A
much safer than azathioprine
12
Q
whats methotrexate
A
a folic acid antagonist
13
Q
which cells are affected most by cyclophosphamide
A
B and T cells equally effected
14
Q
whats cyclophosphamide
A
its an alkylating agent
15
Q
name two calcineurin inhibitors
A
cyclosporin and tacrolimus
