anaemia Flashcards
four types of anaemia
acute haemorrhagic anaemia
iron defiency anaemia
haemolytic anaemias
non regenerating anaemias
where is erythropoietin produced
kidney
what does hypoxia do to erythropoietin production
it increases it -> RBC precursors, reticulocyte and RBC production
indications for erythropoietin as a drug
chronic renal disease
neoplastic diseases
how low should the Ht be before we use erythropoietin as a drug
<20%
why does Ht need to be so low before we can apply EPO
be it triggers an immune response
how should EPO be administered
IV or SC
how often should we apply EPO
3x per week usually
EPO side effects
production of autoantibodies-> no improvement
fever, anorexia, arthalgia, ulceration
what does EPO do to blood pressure and how can this lead to an increase in thromboembolic events
incr blood pressure, incr blood viscosity, incr chance of thromboembolic events
EPO dose
100IU/kg sc until you reach target Ht
two forms of EPO as a drug
epoetin alpha
darbepoetin
which form of EPO drug has a better safety and efficacy
darbepoetin
darbepoetin does it produce more or less autoantibodies
less
darbepoetin is it expensive
yes
