endocrine 2 Flashcards
two groups of hormones affecting repro
sex steroids
other types
sex steroids
oestrogens
androgens
gestagens
other types of repro hormones
GnRH analogues pituitary and non pituitary gonadotropins prostaglandins oxytocin melatonin
GnRH does it have interspecies differences
no
production of GnRH
optic and suprachiasmatic areas of hypothalamus
release of GnRH
pulsatile and cyclic
GnRH actions
stimulation of production and release of FSH and LLH
uses of GnRH
reduce time interval from calving to 1st ovulation
treatment of ovarian follicular cysts in dairy cows
control time of ovulation at end of prostaglandin or progestogen synchronisation schedule
in mares - max chance of conception and nidation
-provoke ovulation in rabbits
-seasonal acyclia in queens
-incr fertility rate in sows and fur farming
-rainbow trout - facilitate stripping, reducing egg binding
-chemical castration
side effects GnRH
- hyperthermia, allergic reaction
- luteal yellow body cysts
- should not be used in pregnant animals
- should not be used in starved, cachetic animals
GnRH makeup
synthetic 9ass forms and analogues are avaliabl
GnRH application
sc, im, sc implants, chemical sterilisation
GnRH items
gonadorelin buserelin fertirelin deslorelin lecirelin
gonadorelin species
horse, cow, rabbit, swine
buserelin species
horse, cow, rabbit, rainbow trout
fertirelin species
cow
deslorelin species
male dogs, SC implant chemical castration - 6month duration
lecirelin species
cow
melatonin is produced where
pineal gland, shows significant diurnal fluctuations
melatonin role
plays a role in regulation of activity levels, winter sleep, reproductive cycles, so it regulates wake up-drowsiness-sleep phase rhythm of body, also affects mating
how is melatonin used in sheep and goats
induce pre season oestrous - authorised in australia and new zealand, sc implant
how is melatonin used in dogs
sedation, alopecia, nasal depigmentation
side effects of melatonin
rapid heartbeat, fatigue, lethargy, hypothermia
FSH and LH makeup
both are glycoproteins, two subunit chains are linked non covalently by disulphide bridges
FSH effects in females
in ovaries incr growth of follicle and estradiol production
FSH effects in males
in the testicles incr in spermatogenesis
LH effects in females
final maturation of follicle - oestrogen production, ovulation, luteotropic in most domestic species
LH effect in males
leydig cells incr testosterone production
why are preparations of FSH and LH rarely used
expensive and short half life
uses of LH
to induce ovulation
lutenize follicular cysts
induce follicular growth and ovulation
uses of FSH
induce follicular growth for the purpose of supra ovulation in donor cows used for embryo transfer
PMSG makeup
large glycoprotein
PMSG where is it released
from endometrial cups of pregnant mares in early pregnancy to maintain a luteotrophic effct on primary and secondary CL
PMSG use in females
induce follicular growth and ovulation
superovulation
PMSG use in males
stimulate spermatogenesis and libido
preparations of PMSG
werfaser inj
gonadophyl inj
suidan inj
how is PMSG used in combo with hCG
treatment of post weaning anoestrous in sows
non pituitary gonadotropins
hCG
hCG makeup
glycoprotein, two peptide chains
where is hCG secreted
from chorionic portion of human placenta
half life of hCG
12-24hr
use of hCG in females
- cause ovulation in the mare at time of breeding
- for the treatment of nymphomania due to cystic ovaries
- for ovarian sitmulation
use of hCG males
in the treatment of cryptochidism
features of natural steroids
fat soluble, short half life, low MW, low oral activity, common structure in all species, not antigenic
what do synthetic and semi synthetic hormones do to specificity
increase
what do synthetic and semi synthetic hormones do to half life
increase
what do synthetic and semi synthetic hormones do to oral absorption
increase
natural oestrogens
oestrone
estradiol 17beta
oestriol
where are natural oestrogens
granulosa cells of ovarian follicle, CL, adrenal cortex, testicles, placenta
absorption of oestrogens
through skin, mucus membranes, GI tract
metabolism of oestrogens
liver
elimination of oestrogens
urine
effects of oestrogens
-development of female sex organs
development and maintainence of secondary female sex characteristics
-cause incr cell height and secretion of cervical mucosa, endometrial proliferation and incr uterine tone
-slight anabolic effect, fat distribution
-release of GnRH
side effects of oestrogens in cows
postpartum straining with prolapse of vagina, uterus
side effects of oestrogens in dog
anaemia, endometritis
side effects of oestrogens
ovarian suppression and hypoplasia - cysts
feminisation in males
should not be given to animals with mammary tumours and during pregnancy
clinical uses of oestrogens in females
- control repro is limited
- treatment of uterine infections
- inhibition of nidation
- treat urinary incontinence and dermatitis in old ovarectimised bitches
- diminish lactation in bitches and queens
- treat cattle having persistant CL due to certain cases
clinical uses of oestrogens in males
anal adenoma, prostate hypertrophy, benign tumour
oestrogens preparations
oestradiol benzoate inj
oestradiol cypionate ecp inj
oestradiol valerate
oestradiol incurin tablet
oestrogens combinations
prolans inj and sesoral tablet
PRID - progesterone releasing intravaginal device - with oestradiol
crestar sc implant
what are stilbenes
synthetic non steroidal oestrogens, have high oral activity, are not easily metabolised, are carcinogens -> prohibited
whats zeranol
synthetic analogue of mould toxin zearalenone with oestrogenic, anabolic activity
anti oestrogen compounds
aromatase inhibitors
oestrogen receptor modulators
raloxifen
clomiphene
when do we use oestrogen receptor modulators
treatment of oestrogen dependant mammary tumours
when do we use raloxifen
antagonist in mammary gland and uterus, agonist in bones
where does clomiphene have its effect
only central
progestagens share two main physio effects of progesterone
nidation and maintainence of pregnancy
suppression of oestrous and blocking ovulation
progesterone physio effects
in pregnant animals it transforms proliferative endometrium to secretory endometrium, inhibits uterine contractility
main uses of natural pregestrone
synchronisation
to prevent embryonic death - not satisfactory
delay parturition - not effective
two types of synthetic preparations of progestagens
strong gestagens - 1st gen
weak gestagens - 2nd gen
when do we use antiprogestagens
to terminate pregnancy
antiprogestagens
aglepristone - sc, second dose after 24hrs
name progestagens
medroxy progesterone fluorogestone acetate norgestomet proligestone and megestrol acetate altrenogest melengestrol acetate
use of medroxy progesterone
- control oestrous and ovulation in cyclic ewes
- induce oestrous in anoestrous ewes as intravaginal sponge
- inhibit onset of the next oestrous in bitches with mid oestrous
medoxy progesterone side effects
cystic endometrial hyperplasia, mammary tumours
fluorogestone acetate use
oestrous synchronisation in ewe
norgestomet use
strong gestagen induce and synchronise ovulation in heifers and cows
proligestone and megestrol acetate what are they
weak progestagens with antigonadotropic effects
proligestone and megestrol acetate use in females
prevent and suppress oestrous and ovulation in companion animals
proligestone and megestrol acetate use in males
anal adenoma, prostate hypertrophy, benign tumour, incr sexual activity, strange behaviour
altrenogest use
oestrous synchronisation
altrenogest is used in which species
mares and sows, po - abasorbed from skin so be careful
melengestrol acetate use
suppress oestrous in heifers and incr growth - banned in EU
melengestrol acetate mechanism of action
form cysts -> elevated oestrogen level
natural androgen compounds
testosterone, dihydrotestosterone, androstenedione
androgens physio effects
-stimulate spermatogenesis
-secondary male characteristics
muscle development
androgens clinical use
- treatment of infertility, hypogonadism, aspermia, decr libido - unsatisfactory
- hormonal alopecia, certain mammary tumours
- to treat androgen deficiency in old castrated dog
- androgenised cows for detection of oestrous in cattle
androgens preparations
andriol caps
retandrol oil inj
sesoral tablets
anabolic steroids use
- not for growth promotion, influencec the race performance
- in ageing animal or patient wiht chronic diseases, polytrauma
- promote recovery from debilitating disease
- stimulation of erythropoietin, brown regeneration
anabolic steroids side effects
vasoconstriction, heart failure, impotence, sperm deformity
anti androgens name them
ciproterone
delmadinon
finasteride
in which species do we use finasteride
boars po
what are prostaglandins
local hormones
when are prostaglandins produced in endometrium
- late in diestrous and cycling animal
- near term in pregnant animal
functions of prostaglandins
in repro
inflammation, membrane protection
other effects of prostaglandins
activity of smooth muscle in uterus, relaxation of cervix
use of prostaglandins
-oestrous synchronisation
induce parturition
-abortion
-treatment pyometra
prostaglandins for use to synchronise oestrous injections
mares 14-18
cows 10-12
goats 11 days apart
how long is CL refractory to PGF in cows
until day 5-7
how long is CL refractory to PGF in ewes
until day 4-5
how long is CL refractory to PGF in mares
until day 5
how long is CL refractory to PGF in sows
until day 12
synthetic analogues of prostaglandins
alfaprostol PGF2alpha dinoprost cloprostenol luprostiol etiproston
side effects of prostaglandin analogues
colic disorders, nausea, vomiting, diarrhoea, bronchoconstriction, abortion
what does progesterone do to the contractile response of uterus
inhibits it
what does oestrogen do to the sensitivity to stimulants
increases it
classifications of uterine stimulants
ecbolics - at term
abortifacients - at any time
types of uterine relaxants
uterine spasmolytics, myometrial depressants, tocolytics, inhibition of oxytocin
types of uterine stimulating agents
oxytocin
prostaglandins
ergot alkaloids
cholinergic/parasympathetic drugs
what is important to remember with ecbolics
use with caution if cervix not fully dilated
indications for uterine stimulating agents
during prolonged parturition
- to promote involution
- for post parturient haemorrhage
oxytocin production
hypothalamus, stored in posterior pituitary
oxytocin makeup
consists of 9 amino acids
oxytocin release is controlled by
- adrenergic and cholinergic pathway
- opioid peptides
- oestrogen
oxytocin has its action where
myometrium, mammary gland
oxytocin mode of action
binding to receptors -> resting potential changed -> Ca channels oppened -> Ca incr-> contraction and prostaglandin release
side effects of oxytocin
GI
cardiovascular system, swelling at inj site
oxytocin uses
- uterin inertia
- retention of eggs
- after parturition
- milk let down
- after caesarian
- after reposition of prolapsed uterus
admin routes of synthetic oxytocin
iv, im ,sc
metabolism of synthetic oxytocin
fast
whats carbetocin
synthetic analogue of oxytocin
half life of cabectocin
much longer
antioxytocin
atosiban, iv use, tocolytic action
where are ergot alkaloids produced
by claviceps purpurea in rye and other cereals
major effects of ergot alkaloids
arithmetic contractions of uterus
peripheral constrictions of vessels
synthetic derivatives of ergot alkaloids effects
dopaminergic effect, reduction of prolactin hormone synthesis
indication of ergot alkaloids
pseudopregnancy, abortion, synchronisation
name three ergot alkaloids
bromocriptine
pergolide
cabergoline
three types of ergot alkaloids
ergotoxins
ergotamine
ergometrine
ergometrine use
post partum
potent uterine stimulant
rarely used during parturition
methyl ergometrine what is it
ergot alkaloid
methyl ergometrine does it have vasoconstrictor activity
no
can methyl ergometrine be used in combo
yes, with oxytocin
uses for uterine relaxing agents
prevent abortion
suppress contractions during correction of malpresentatin, embryotomy, obstetrical manoeuver
groups of uterine relaxing agents
beta2 adrenoceptor agonists
antispasmodics
phenothiazines
anticholinergics
beta2 adrenoceptor agonist uses
reversible myometrial relaxation
facilitating obstetrical maneouvers
replacement of prolapsed uterus
handling of uterus durind C section
name three beta2 adrenoceptor agonists
isoxuprine
clenbuterol
terbutaline
side effects beta2 adrenoceptor agonists
tachycardia, vasodilation, tremor, sweating
vetrabutin what is its
papverine like drug, uterine relaxing agent
vetrabutin mechanism of action
interrupts the contractions caused by oxytocin, not as effective as clenbuterol
vetrabutin can it be used in cats
no
denaverine what is it
uterine relaxant
denaverine effect
toco spasmolytic effect, elimination of too sensitive contractions of uterus, relaxes cervix
proqumezine what is it
uterine muscle relaxant, phenothizine derivative
proquamezine effect
relaxes myometrium and cervix
proquamezine indications
reposition of prolapsed uterus, spasm of urinary tract or oresophagus