antidepressants and behaviour modifying drugs Flashcards

1
Q

indications

A
  • aggression
  • seperation anxiety
  • recurring behaviour
  • phonophobia
  • property protection
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2
Q

drug groups

A
  • neuroleptics
  • benzodiazepines
  • antidepressants
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3
Q

examples of neuroleptics

A
  • phenotiazines

- butryophenons

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4
Q

neuroleptics effects

A
  • more or less sedative effect

- extrapyramidal side effects

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5
Q

phenothiazine features -acepromazine

A
  • both normal and abnormal behaviour is suppressed - not effective for treating abnormal behaviour
  • ataraxia - decr reactions and stress senstivity
  • aggressive dog - more sensitive to noises
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6
Q

name three benzodiazepines used as antidepressants

A
  • alprazolam
  • diazepam
  • lorazepam
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7
Q

antidepressants features

A
  • no/slight sedation
  • slow onset of action, delayed elimination
  • lots of interactions
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8
Q

main groups of antidepressant drugs

A
  • tricyclic antidepressants, TCA
  • selective serotinin reuptake inhibitors, SSRI
  • monoamine-oxidase inhibitors MAOi
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9
Q

examples of tricyclic antidepressants

A
  • clomipramine

- amitriptyline

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10
Q

examples of selective serotonin reuptake inhibitors

A
  • fluoxetine

- sertraline

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11
Q

examples of monoamino-oxidase inhibitors

A

selegiline

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12
Q

are MAOi specific

A

no

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13
Q

do MAOi breakdown

A

no

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14
Q

selegiline metabolites

A

amphetamine, metamphetamine - abuse

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15
Q

selegiline indications

A
  • cognitive dysfunction in dogs and cats

- sleep disorders, recurring behaviours

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16
Q

selegiline side effects

A
  • emesis
  • diarrhoea
  • excitation
  • anorexia
17
Q

selegiline interactions

A

other antidepressants

18
Q

non specific TCAs

A

serotonin, norepinephrine, no reuptake

19
Q

most specific TCA

A

clomipramine

20
Q

TCA effect

A

slow

21
Q

clomipramine usage

A

per os with food

22
Q

clomipramine indications

A
  • recurring behaviours -acral lick dermatitis, tail chasing
  • phonophobia
  • fe - vocalisation, pyschogenic alopecia, incontinence, FIC
23
Q

clomipramine side effects

A
  • emesis, diarrhoea
  • tachycardia
  • arrythmia
  • anticolinergic
24
Q

SSRIs features

A
  • most specific, safest
  • least sedative
  • no tachycardia
25
Q

fluoxetine usage

A

per os

26
Q

fluoxetine elimination

A

norfluoxetine in liver -> slow elimination, atleast 2 weeks

27
Q

fluoxetine side effects

A
  • sedation
  • emesis
  • diarrhoea
  • appetite decrease
  • convulsion - no combo with other convulsants
28
Q

fluoxetine interactions?

A

lots

29
Q

sertraline usage

A

per os

30
Q

sertraline indications

A
  • recurring behaviours
  • seperation anxiety
  • dominant aggression
  • phonophobia
31
Q

mirtrazapine effect

A

slightly sedative

32
Q

mirtrazapine elimination

A

half life 20-40hrs, steady state 4-6days

33
Q

mirtrazapine

A

serotonin antagonist in GI -> antiemetic- appetite incr

34
Q

alpha-casozepine features

A
  • from milk, casein hydrolysate, BDZ-like effect -anxiolytic
  • no effect on memory, no paradox activity
  • both short and longterm
35
Q

other natural substances that could be used

A
  • DAP, dog appeasing feromone, Feliway
  • calm foods
  • tryptophan
  • alpha-theanine
  • catnip