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Naplex ID Section > Sulfonamides > Flashcards

Sulfonamides Flashcards

1
Q

MOA of Sulfonamides

A

Sulfamethoxazole inhibits dihydrofolic acid formation.
Trimethoprim inhibits dihydrofolic acid reduction
Together: inhibit folic acid pathway

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2
Q

Sulfamethoxazole/Trimethoprim covers?

A

Staphylococci including MRSA and CA-MRSA, Gram negative bacteria HPEK, Enterobacter, Shigella, Salmonella, and Stentrophomonas, opportunistic pathogens Nocardia, penumocystis, toxoplasmosis

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3
Q

Brand name of Sulfamethoxazole/Trimethoprim

A

Bactrim and Bactrim DS

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4
Q

The dose of Sulfamethoxazole/Trimethoprim is based on what component?

A

Trimethoprim component

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5
Q

What is the dose of Single Strength Sulfamethoxazole/Trimethoprim

A

400mg SMX/80mg TMP

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6
Q

What is the dose of Double Strength Sulfamethoxazole/Trimethoprim

A

800mg SMX/ 160mg TMP

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7
Q

What is the dose of Sulfamethoxazole/Trimethoprim for uncomplicated UTI

A

1 DS tablet PO BID x 3 days

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8
Q

What is the dose of Sulfamethoxazole/Trimethoprim for pneumocystis Pneumonia (PCP) prophylaxis

A

1 DS or SS tablet daily

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9
Q

Contraindications for Sulfamethoxazole/Trimethoprim

A

Sulfa allergy, pregnant, and breastfeeding

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10
Q

Warnings with Sulfamethoxazole/Trimethoprim

A

Skin reactions: SJS/TEN, thrombotic thrombocytopenic purpura

G6PD deficiency

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11
Q

Side effects of Sulfamethoxazole/Trimethoprim

A

Photosensitivity, increased potassium, hemolytic anemia, crystalluria

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12
Q

Drug-drug interactions of Sulfamethoxazole/Trimethoprim

A

Moderate-strong inhibitor of CYP2C9 and can increase INR, caution when using warfarin

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13
Q

What is the ratio of Sulfamethoxazole to Trimethoprim

A

5:1

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14
Q

What lowers levels of Sulfamethoxazole/Trimethoprim

A

CYP2C8 and CYP2C9 inducers

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Naplex ID Section (21 decks)

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