Oxazolidinones

Question 1

MOA of oxazolidinones

Answer 1

Bind to 50S subunit of the bacterial ribosome, inhibit protein synthesis

Question 2

Coverage of Oxazolidinones

Answer 2

Gram positive coverage, staphylococci (MRSA), and VRE

Question 3

List the Oxazolidinones

Answer 3

1) Linezolid

2) Tedizolid

Question 4

Brand name of linezolid

Answer 4

Zyvox

Question 5

True or false, dose adjustment or linezolid is needed for renal impairment

Answer 5

False

Question 6

IV:PO ratio of Linezolid

Answer 6

1:1

Question 7

Contraindication of Linezolid

Answer 7

Do not use with or within 2 weeks of MAO inhibitors

Question 8

Warnings of Linezolid

Answer 8

Duration-related myelosuppression (thrombocytopeniaP), optic neuropathy when used > 28 days, serotonin syndrome, hypoglycemia

Question 9

Side effect of linezolid

Answer 9

Decrease in platelets

Question 10

True or false, it is appropriate to shake linezolid suspension

Answer 10

False

Question 11

True or false, linezolid and tedizolid are reversible monoamine oxidase inhibitors?

Answer 11

True

Question 12

What should a patient avoid when taking linezolid or tedizolid?

Answer 12

Tyramine-containing foods and serotonergic drugs