Macrolides

Question 1

MOA of macrolides

Answer 1

Bind to 50S ribosomal subunit and inhibit RNA-dependent protein synthesis

Question 2

Macrolides have good coverage of what?

Answer 2

Atypicals

Question 3

Macrolides are used in what infections

Answer 3

Community acquired upper and lower respiratory tract infections, sexually transmitted diseases i.e. chlamydia and gonorrhea

Question 4

Brand name of Azithromycin

Answer 4

Zithromax, Z-Pak

Question 5

Dosing of Azithromycin

Answer 5

Z-Pak: 500mg day 1, then 250mg day 2-5

Tri-Pak: 500mg daily for three days

Question 6

List of macrolides

Answer 6

1) Azithromycin
2) Clarithromycin
3) Erythromycin

Question 7

Brand name of Erythromycin

Answer 7

E.E.S., Ery-tab, Erythrocin

Question 8

Contraindication of Clarithromycin and Erythromycin

Answer 8

Contraindicated use with lovastatin and simvastatin because Clarithromycin and Erythromycin are CYP 3A4 inhibitors

Question 9

What should be closely watched with Clarithromycin and Erythromycin

Answer 9

DOACs and Warfarin

Question 10

True or False Azithromycin has fewer clinically significant drug-drug interactions

Answer 10

True

Question 11

What are the warnings with the Macrolides

Answer 11

QT prolongation, Hepatotoxicity, Use in patients with cardiovascular disease (specifically clarithromycin)

Question 12

Side effects of macrolides

Answer 12

GI upset