Macrolides Flashcards
MOA of macrolides
Bind to 50S ribosomal subunit and inhibit RNA-dependent protein synthesis
Macrolides have good coverage of what?
Atypicals
Macrolides are used in what infections
Community acquired upper and lower respiratory tract infections, sexually transmitted diseases i.e. chlamydia and gonorrhea
Brand name of Azithromycin
Zithromax, Z-Pak
Dosing of Azithromycin
Z-Pak: 500mg day 1, then 250mg day 2-5
Tri-Pak: 500mg daily for three days
List of macrolides
1) Azithromycin
2) Clarithromycin
3) Erythromycin
Brand name of Erythromycin
E.E.S., Ery-tab, Erythrocin
Contraindication of Clarithromycin and Erythromycin
Contraindicated use with lovastatin and simvastatin because Clarithromycin and Erythromycin are CYP 3A4 inhibitors
What should be closely watched with Clarithromycin and Erythromycin
DOACs and Warfarin
True or False Azithromycin has fewer clinically significant drug-drug interactions
True
What are the warnings with the Macrolides
QT prolongation, Hepatotoxicity, Use in patients with cardiovascular disease (specifically clarithromycin)
Side effects of macrolides
GI upset