Macrolides Flashcards

1
Q

MOA of macrolides

A

Bind to 50S ribosomal subunit and inhibit RNA-dependent protein synthesis

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2
Q

Macrolides have good coverage of what?

A

Atypicals

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3
Q

Macrolides are used in what infections

A

Community acquired upper and lower respiratory tract infections, sexually transmitted diseases i.e. chlamydia and gonorrhea

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4
Q

Brand name of Azithromycin

A

Zithromax, Z-Pak

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5
Q

Dosing of Azithromycin

A

Z-Pak: 500mg day 1, then 250mg day 2-5

Tri-Pak: 500mg daily for three days

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6
Q

List of macrolides

A

1) Azithromycin
2) Clarithromycin
3) Erythromycin

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7
Q

Brand name of Erythromycin

A

E.E.S., Ery-tab, Erythrocin

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8
Q

Contraindication of Clarithromycin and Erythromycin

A

Contraindicated use with lovastatin and simvastatin because Clarithromycin and Erythromycin are CYP 3A4 inhibitors

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9
Q

What should be closely watched with Clarithromycin and Erythromycin

A

DOACs and Warfarin

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10
Q

True or False Azithromycin has fewer clinically significant drug-drug interactions

A

True

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11
Q

What are the warnings with the Macrolides

A

QT prolongation, Hepatotoxicity, Use in patients with cardiovascular disease (specifically clarithromycin)

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12
Q

Side effects of macrolides

A

GI upset

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