Cyclic Lipopeptide

Question 1

MOA of Daptomycin

Answer 1

Binds to cell membrane components causing rapid depolarization

Question 2

True or False, Daptomycin has concentration-dependent antibacterial activity

Answer 2

True

Question 3

Daptomycin coverage

Answer 3

Gramp positive Staphylococci (MRSA), Enterococci (Both species of VRE)

Question 4

Brand name of Daptomycin

Answer 4

Cubicin, Cubicin RF

Question 5

True or false, daptomycin can be used to treat pneumonia?

Answer 5

False because the drug is inactivated by the surfactant in the lungs

Question 6

What are the warnings to consider with daptomycin

Answer 6

Rhabdomyolysis and Myopathy, can falsely elevIate PT/INR

Question 7

What are the side effects of Daptomycin

Answer 7

Increase in CPK (creatine phosphokinase)

Question 8

What should be monitored with Daptomycin

Answer 8

Monitor CPK level weekly

Question 9

What is Cubicin and Cubicin RF compatible with?

Answer 9

Cubicin: normal saline and Lactated ringer (no dextrose)
Cubicin RF: Normal saline (no dextrose) but must use sterile or bacteriostatic water for injection to reconstitute the lyophilized powder before diluting further with normal saline