Tetracyclines Flashcards

1
Q

MOA of tetracyclines

A

Inhibit bacterial protein synthesis by binding to 30S ribosomal subunit

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2
Q

Coverage of Tetracycline

A

Gram Positive, Gram negative (including Haemophilus, Moraxella), atypicals and other unique pathogens

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3
Q

Doxycycline has broader coverage, what else does it cover?

A

CAP, Tick-borne/rickettsial diseases, spirochetes, sexually transmitted diseases chlamydia and gonorrhea, mild skin infections caused by CA-MRSA, and VRE urinary tract infections

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4
Q

Minocycline is preferred for treatment of what?

A

Skin infections including acne

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5
Q

Brand name of doxycycline

A

Vibramycin

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6
Q

True or false doxycycline needs to be renally adjusted

A

False

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7
Q

Brand name of minocycline

A

Minocin, Solodyn

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8
Q

Tetracyclines should not be used in what patient population and why?

A

Pregnancy, breastfeeding or children < 8 y/o because of suppressed bone growth and discoloration of teeth

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9
Q

Warning for tetracyclines?

A

Teeth discoloration, suppressing child’s growth, and photosensitivity

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10
Q

Warning for minocycline specifically

A

Drug induced lupus erythematosus (DILE)

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11
Q

IV:PO ratio for doxycycline and minocycline

A

1:1

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12
Q

What are the special administration directions with doxycycline?

A

Sit up right for 30 minutes after dose

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13
Q

Major DDI with tetracyclines

A

Antacids, polyvalent cations, sucralfate, bismuth subsalicylate and bile resins can cause chelation and inhibit tetracycline absorption.

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