Tetracyclines

Question 1

MOA of tetracyclines

Answer 1

Inhibit bacterial protein synthesis by binding to 30S ribosomal subunit

Question 2

Coverage of Tetracycline

Answer 2

Gram Positive, Gram negative (including Haemophilus, Moraxella), atypicals and other unique pathogens

Question 3

Doxycycline has broader coverage, what else does it cover?

Answer 3

CAP, Tick-borne/rickettsial diseases, spirochetes, sexually transmitted diseases chlamydia and gonorrhea, mild skin infections caused by CA-MRSA, and VRE urinary tract infections

Question 4

Minocycline is preferred for treatment of what?

Answer 4

Skin infections including acne

Question 5

Brand name of doxycycline

Answer 5

Vibramycin

Question 6

True or false doxycycline needs to be renally adjusted

Answer 6

False

Question 7

Brand name of minocycline

Answer 7

Minocin, Solodyn

Question 8

Tetracyclines should not be used in what patient population and why?

Answer 8

Pregnancy, breastfeeding or children < 8 y/o because of suppressed bone growth and discoloration of teeth

Question 9

Warning for tetracyclines?

Answer 9

Teeth discoloration, suppressing child’s growth, and photosensitivity

Question 10

Warning for minocycline specifically

Answer 10

Drug induced lupus erythematosus (DILE)

Question 11

IV:PO ratio for doxycycline and minocycline

Answer 11

1:1

Question 12

What are the special administration directions with doxycycline?

Answer 12

Sit up right for 30 minutes after dose

Question 13

Major DDI with tetracyclines

Answer 13

Antacids, polyvalent cations, sucralfate, bismuth subsalicylate and bile resins can cause chelation and inhibit tetracycline absorption.