Glycopeptide

Question 1

MOA of Vancomycin

Answer 1

Inhibits bacterial cell wall synthesis by binding to D-alanyl-D-alanine cell wall

Question 2

Vancomycin covers?

Answer 2

Gram positive bacteria staphylococci (MRSA), Streptococci, Enterococci (NOT VRE), C. difficile (PO route)

Question 3

Brand name of vancomycin

Answer 3

Vancocin

Question 4

True or False, vancomycin is first line treatment for MRSA infections

Answer 4

True

Question 5

When should an alternative drug being used for MRSA

Answer 5

When MIC >/ 2 mcg/mL

Question 6

What is the dose for vancomycin systemic infection

Answer 6

IV 15-20 mg/kg Q8-12H; dose based on total body weight

Question 7

What is the dose adjustment of vancomycin when CrCl is 20-49 mL/min

Answer 7

Q24H

Question 8

What is the dose for vancomycin C.difficle

Answer 8

PO 250-500mg QID x 10 days

Question 9

Warning of Vancomycin

Answer 9

Ototoxicity and nephrotoxicity, infusion reaction/red man syndrome (do not infuse faster than 1g per hour)

Question 10

What should be monitored with vancomycin

Answer 10

Renal function, AUC/MIC ratio or trough

Question 11

What is the AUC/MIC ratio or goal trough for serious MRSA infections

Answer 11

AUC/MIC ratio: 400-600

Goal trough: 15-20mcg/ mL