Lipoglycopeptide

Question 1

MOA of Lipoglycopeptides

Answer 1

Inhibit bacterial cell wall synthesis by binding to D-alanyl-D-alanine

Question 2

True or False, lipoglycopeptides have concentration dependent antibacterial activity

Answer 2

True

Question 3

What is the difference between lipoglycopeptides and vancomycin

Answer 3

Lipoglycopeptides only come as IV formulation and do not treat C. Difficile

Question 4

List the lipoglycopeptides

Answer 4

1) Telavancin
2) Oritavancin
3) Dalbavancin

Question 5

Telavancin is approved for?

Answer 5

Complicated skin and soft tissue infections

Question 6

What is the boxed warning for Telavancin?

Answer 6

Fetal risk and nephrotoxicity

Question 7

Contraindication of Telavancin

Answer 7

Concurrent use of IV unfractionated heparin

Question 8

What are the warnings of Telavancin

Answer 8

Can falsely elevate coagulation tests (aPTT/PT/INR), red man syndrome

Question 9

Contraindication of Oritavancin

Answer 9

Use of IV UFH for 120 hours (5 days) after oritavancin administration

Question 10

Warnings of Oritavancin and Dalbavancin

Answer 10

Can cause falsely elevated PT/INR for up to 12 hours and aPTT for up to 120 hours after a dose

Question 11

True or false if osteomyelitis is confirmed or suspected, oritavancin can be used?

Answer 11

False, use a different antibiotic

Question 12

Side effects of oritavancin and dalbavancin

Answer 12

Infusion reaction (red man syndrome)

Question 13

True or false, oritavancin and dalbavancin have extremely long half-lives and that allows for a single-dose regimen

Answer 13

True

Question 14

Televancin should be avoided in what patient population

Answer 14

Patients with congenital long QT syndrome or known QT prolongation or uncompensated heart failure

Question 15

What is different about telavancin and oritavancin than dalbavancin

Answer 15

Dalbavancin is a cell wall inhibitor only

Telavancin and Oritavancin are both cell wall inhibitors and cell membrane inhibitors