Penicillins

Question 1

What are the natural penicillins

Answer 1

1) Penicillin V potassium
2) Penicillin G Aqueous
3) Penicillin G Benzathine
4) Penicillin G Procaine

Question 2

What is the brand name of Penicillin G Benzathine

Answer 2

Bicillin L-A

Question 3

What is the black box warning of Penicillin G Benzathine

Answer 3

Not for IV use; can cause cardio-respiratory arrest and death

Question 4

What are the aminopenicillins?

Answer 4

1) Amoxicillin
2) Amoxicillin/Clavulanate
3) Ampicillin
4) Ampicillin/Sulbactam

Question 5

What are dosage forms of Amoxicillin

Answer 5

Tablet, capsule, chewable, suspension

Question 6

What is the brand name for Amoxicillin/Clavulanate

Answer 6

Augmentin

Question 7

What are the dosage forms of Amoxicillin/Clavulanate

Answer 7

Tablet, chewable, suspension

Question 8

What are the dosage forms of Ampicillin

Answer 8

Injection, capsule, suspension

Question 9

What is the brand name of Ampicillin/Sulbactam

Answer 9

Unasyn

Question 10

How should Penicillin G Benzathine be given?

Answer 10

IM

Question 11

What is the dosage form of Ampicillin/Sulbactam

Answer 11

Innjection

Question 12

What is a contraindication for aminopenacillins

Answer 12

In severe renal impairment CrCl < 30 mL/min, do not use extended-release oral forms of amoxicillin and amoxicillin/clavulanate, or 875 mg strength of amoxicillin / clavulanate

Question 13

What are the extended-spectrum penicillins

Answer 13

Pipercillin/Tazobactam

Question 14

What is the brand name of pipercillin/tazobactam

Answer 14

Zosyn

Question 15

What is the dosage form of pipercillin/tazobactam

Answer 15

Injection

Question 16

How should pipercillin/tazobactam be prolonged or extended infused

Answer 16

3.375-4.5 g IV Q8H, each dose infused over 4 hours

Question 17

What are class wide side effects of penicillins

Answer 17

Seizures with accumulation, GI upset, rash including SJS/TEN

Question 18

IV ampicillin and ampicillin/sulbactam must be diluted inn what

Answer 18

Normal saline only

Question 19

What are the anti-staphylococcal penicillins

Answer 19

1) Dicloxacillin
2) Nafcillin
3) Oxacillin

Question 20

What is the dosage form of Naficillin

Answer 20

Injection

Question 21

What type of penicillin is preferred for MSSA soft tissue, bone and joint, endocarditis, and bloodstream infections

Answer 21

Anti-staphylococcal penicillins

Question 22

True or false, renal adjustment is required for Anti-staphylococcal penicillins

Answer 22

False

Question 23

How should naficillin be administered and why

Answer 23

Through a central line because it is an vesicant

Question 24

What happens if naficillin extravasation occurs

Answer 24

Use cold packs and hyaluronidase injections

Question 25

Probenecid has what affect on beta-lactams

Answer 25

Increases the levels of beta-lactams

Question 26

Penicillin VK is first line treatment for?

Answer 26

Outpatient: Strep throat and mild non purulent skin infections

Question 27

Amoxicillin is is first line treatment for?

Answer 27

Outpatient: Acute otitis media, Infective endocarditis prophylaxis before dental procedures

Question 28

True or false? Dicloxacillin and Oxacillin cover MSSA only

Answer 28

True

Question 29

Amoxicillin/Clavulanate is first line treatment for?

Answer 29

Outpatient: Otitis media and sinus infection

Question 30

How should Amoxicillin/Clavulanate be dosed?

Answer 30

Using lowest dose of Clavulanate to decrease diarrhea

Question 31

Penicillin G Benzathine is drug of choice for?

Answer 31

Syphilis

Question 32

True or false, Zosyn is the only penicillin active against pseudomonas?

Answer 32

True