Lincosamide Flashcards
1
Q
MOA of Clindamycin
A
Reversibly binds to 50S subunit of ribosome inhibiting protein synthesis
2
Q
Coverage of Clindamycin
A
Most anaerobes and gram positive bacteria
3
Q
What does Clindamycin not cover
A
Enterococcus or gram negative pathogens
4
Q
Brand name of clindamycin
A
Cleocin
5
Q
Brand name of clindamycin as a topical
A
Cleocin-T, Clindagel
6
Q
True or false, clindamycin requires dose adjustment with renal impairment
A
False
7
Q
Boxed warning of clindamycin
A
Colitis (C. difficile)
8
Q
Side effects of clindamycin
A
N/V/D
9
Q
When should clindamycin not be used?
A
An induction test (D-Test) preformed on S. Aureus that is susceptible to clindamycin but resistant to erythromycin; a flattened zone between disks (positive D-test) indicates inducible clindamycin resistance and should not be used.
