Quinolones

Question 1

What is the MOA of Quinolones?

Answer 1

Inhibit DNA topoisomerase IV and DNA gyros; promotes breakage of double stranded DNA

Question 2

Quinolones have what type antibacterial activity?

Answer 2

Concentration-dependent

Question 3

What are the respiratory quinolones?

Answer 3

Gemifloxacin
Levofloxacin
Moxifloxacin

Question 4

Respiratory quinolones have great coverage of what?

Answer 4

S. Pneumoniae and atypical coverage

Question 5

Ciprofloxacin and Levofloxacin have coverage of what?

Answer 5

Gram negative including Pseudomonas

Question 6

Moxifloxacin has enhanced coverage of what?

Answer 6

Gram positive and anaerobic activity

Question 7

True or False, Moxifloxacin cannot be used to treat urinary tract infection

Answer 7

true

Question 8

What was Delafloxacin approved for?

Answer 8

Skin infections, active against MRSA, other quinolones should be avoided

Question 9

What can chelate and inhibit quinolone absorption

Answer 9

antacids and other polyvalent cations

Question 10

What is the effect of Lanthanum Carbonate and sevelamer on oral quinolones

Answer 10

Decrease the serum concentration; separate by 2 hours before or after lanthanum or 6 hours after sevelamer

Question 11

What is the brand name of Ciprofloxacin

Answer 11

Cipro

Question 12

What is the brand name of ciprofloxacin + dexamethasone

Answer 12

Ciprodex

Question 13

What is the brand name of levofloxacin

Answer 13

Levaquin

Question 14

What is the brand name of Moxifloxacin

Answer 14

Avelox

Question 15

True or false, moxifloxacin needs to be renally adjusted

Answer 15

False

Question 16

Brand name of ofloxacin

Answer 16

Ocuflox

Question 17

What are the boxed warning of quinolones

Answer 17

1) Tendon inflammation and/or rupture
2) Peripheral neuropathy
3) CNS effects - use caution in patients with CNS disorders or with drugs that cause seizures

Question 18

Which quinolone has the highest QT prolongation risk

Answer 18

Moxifloxacin

Question 19

What are some warnings of quinolones

Answer 19

1) QT prolongation
2) Hypoglycemia and hyperglycemia
3) Psychiatric disturbances
4) Photosensitivity

Question 20

Quinolones should be avoided in what populations

Answer 20

Elderly, children, pregnancy/breast feeding women

Question 21

True or false, cipro oral suspension can be given through an NG tube or other feeding tube

Answer 21

False

Question 22

What is the IV to PO ratio for levofloxacin and moxifloxacin

Answer 22

1:1

Question 23

List all of the quinolones

Answer 23

1) Ciprofloxacin
2) Levofloxacin
3) Moxifloxacin
4) Delafloxacin
5) Gatifloxacin
6) Gemifloxacin
7) Ofloxacin