Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Naplex ID Section > HIV > Flashcards

HIV Flashcards

1
Q

What drug(s) work on the binding/attachment stage?

A

1) Maraviroc (Selzentry)

2) Ibalizumab-uiyk (Trogarzo)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What drug(s) work on the fusion stage?

A

1) Enfuviritide (Fuzeon)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What drug(s) work on the reverse transcription stage?

A

1) Non-nucleoside reverse transcriptase inhibitors

2) Nucleoside reverse transcriptase inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What drug(s) work on the integration stage?

A

1) Integrase strand transfer inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What drug(s) work on the budding and maturation stage?

A

1) Protease inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Biktarvy =

Dosing

A

Bictegravir
Emtricitabine
Tenofovir alafenamide
One pill once a day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Triumeq =

Dosing

A

Dolutegravir
Abacavir
Lamivudine
One pill once a day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Dovato =

Dosing

A

Dolutegravir
Lamivudine
One pill once a day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Tivicay + Truvada =

A

Dolutegravir
+
Emtricitabine / Tenofovir disoproxil fumarate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Tivicay + Descovy =

A

Dolutegravir
+
Emtricitabine/Tenofovir alafenamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Isentress + Truvada =

A

Raltegravir
+
Emtricitabine / Tenofovir disoproxil fumarate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Isentress + Descovy =

A

Raltegravir
+
Emtricitabine/Tenofovir alafenamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which HIV drug requires testing of HLA-B*5701 allel

A

Abacavir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

TDF or TAF has more renal and bone density issues?

A

TDF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which combination one pill once daily should not be used if there is a hepatitis B co-infection or if HIV RNA > 500,000

A

Dovato

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

List the Nucleoside reverse transcriptase inhibitors

A

1) Tenofovir disoproxil fumarate (Viread)
2) Tenofovir alafenamide (Vemlidy)
3) Lamivudine (Epivir)
4) Emtricitabine (Emtriva)
5) Abacavir (Ziagen)
6) Zidovudine (Retrovir)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Which NRTI is give to a mother via IV during birth if mother’s viral load >1000 copies/mL?

A

Zidovudine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

MOA of NRTI

A

Competitively block (inhibit) reverse transcriptase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Which NRTI does not require renal dose adjustment

A

Abacavir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is the first line ART regimens, if treatment-naïve

A

1 or 2 NRTIs as the backbone with an NSTI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Boxed warning of NRTIs

A

Lactic acidosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Abacavir, tenofovir, and lamivudine all have what warning?

A

Hepatomegaly with steatosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

True or false: Abacavir can be used if treating both HIV and Hep B?

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

True or false: Emtricitabine can be replaced with lamivudine but they cannot be used together?

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
List all of the INSTIs
1) Bictegravir 2) Elvitegravir (EVG) 3) Dolutegravir (Tivicay) 4) Raltegravir
26
How far apart do INSTIs and cations need to be separated?
INSTIs two hours before or 6 hours after
27
MOA of INSTIs
Block the integrate preventing viral DNA from integrating into the hose cell DNA
28
List all the in NNRTIs
1) Efavirenz | 2) Rilpivirine
29
MOA of NNRTIs
Inhibits reverse transcriptase enzyme by binding non-competitively
30
Which NNRTIs are taken with food
Rilpivirine
31
True or false: All NNRTIs are inducers and inhibitors except Rilpivirine
True
32
Boxed warning of NNRTIs
1) Hepatotoxicity | 2) Severe Rash
33
Which NNRTI causes psychiatric symptoms such as abnormal dreams
Efavirenz
34
When can Rilpivirine not be used?
1) Viral load > 100,000 copies | 2) CD4+ counts < 200
35
List all the PIs
1) Atazanavir (Reyataz) | 2) Darunavir (Prezista)
36
MOA of PIs
Inhibit protease enzyme
37
True or false: Both Atazanavir and Darunavir should be given with boosters ritonavir 100mg or cobicistat 150mg
True
38
True or false: Atazanavir and Darunavir should be taken with food?
True
39
Atazanavir could cause?
Hyperbilirubinemia, PR interval prolongation, and skin reactions
40
True or false: With darunavir you must use caution with. a sulfa allergy
True
41
Which drugs should not be used with PIs
1) Alfuzosin 2) Colchicine 3) Dronedarone 4) Amiodarone 5) Apixaban 6) edoxaban 7) Rivaroxaban 8) Direct-acting antivirals 9) Hormonal contraceptives 10) Lovastatin 11) Simvastatin
42
List the boosters
1) Ritonavir (Norvir) | 2) Cobicistat (Tybost)
43
True or false: ritonavir and cobicistat are interchangeable
False
44
What is the contraindication of boosters?
Use with narrow therapeutic index drug that is cleared via CYP3A4
45
When should Stribild not be used?
When CrCl < 50mL/min
46
What is in Stribild?
Elvitegravir Cobicistat Emtricitabine Tenofovir disoproxil fumarate
47
When should Genvoya not be used?
CrCl < 30mL/min
48
What is in Genvoya
Elvitegravir Cobicistat Emtricitabine Tenofovir alafenamide
49
What drug is a CCR5 Antagonist?
Maraviroc
50
What is required to start Maraviroc
Must have tropism because it only works with CCR5-tropic disease aka CCR5 receptors are the ONLY ONES present
51
How is the fusion inhibitor, Enfuvirtide given?
90mg SC BID
52
True or false Fuzeon requires reconstitution?
True
53
AIDS is diagnosed when?
CD4+ count < 200 Opportunistic infection Kaposi's sarcoma HIV wasting syndrome
54
PrEP is used when and which drugs are used?
Before high-risk activity taken daily | Truvada or Descovy
55
True or false: before starting PrEP, patient should have a HIV-negative antibody test
True
56
How often should a patient follow-up when taking PrEP?
Every 3 months
57
Pep is used when and which drugs are used?
After HIV-exposure within 72 hours and taken for 28 days. Truvada + Dolutegravir or Raltegravir
58
What is in Atripla?
Efavirenz Tenofovir disproval fumarate Emtricitabine
59
What is in Complera?
Rilpivirine Tenofovir disproval fumarate Emtricitabine
60
What is in Odefsey?
Rilpivirine Emtricitabine Tenofovir alafenamide
61
What is in Epzicom?
Abacavir | Lamivudine
62
Retrovir is the brand name of?
Zidovudine
63
Isentress, Isentress HD is the brand name of?
Raltegravir
64
Tivicay is the brand name of?
Dolutegravir
65
Prezista is the brand name of?
Darunavir
66
Reyataz is the brand name of?
Atazanavir

Naplex ID Section (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions