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HIV Flashcards

1
Q

What drug(s) work on the binding/attachment stage?

A

1) Maraviroc (Selzentry)

2) Ibalizumab-uiyk (Trogarzo)

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2
Q

What drug(s) work on the fusion stage?

A

1) Enfuviritide (Fuzeon)

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3
Q

What drug(s) work on the reverse transcription stage?

A

1) Non-nucleoside reverse transcriptase inhibitors

2) Nucleoside reverse transcriptase inhibitors

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4
Q

What drug(s) work on the integration stage?

A

1) Integrase strand transfer inhibitors

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5
Q

What drug(s) work on the budding and maturation stage?

A

1) Protease inhibitors

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6
Q

Biktarvy =

Dosing

A

Bictegravir
Emtricitabine
Tenofovir alafenamide
One pill once a day

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7
Q

Triumeq =

Dosing

A

Dolutegravir
Abacavir
Lamivudine
One pill once a day

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8
Q

Dovato =

Dosing

A

Dolutegravir
Lamivudine
One pill once a day

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9
Q

Tivicay + Truvada =

A

Dolutegravir
+
Emtricitabine / Tenofovir disoproxil fumarate

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10
Q

Tivicay + Descovy =

A

Dolutegravir
+
Emtricitabine/Tenofovir alafenamide

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11
Q

Isentress + Truvada =

A

Raltegravir
+
Emtricitabine / Tenofovir disoproxil fumarate

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12
Q

Isentress + Descovy =

A

Raltegravir
+
Emtricitabine/Tenofovir alafenamide

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13
Q

Which HIV drug requires testing of HLA-B*5701 allel

A

Abacavir

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14
Q

TDF or TAF has more renal and bone density issues?

A

TDF

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15
Q

Which combination one pill once daily should not be used if there is a hepatitis B co-infection or if HIV RNA > 500,000

A

Dovato

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16
Q

List the Nucleoside reverse transcriptase inhibitors

A

1) Tenofovir disoproxil fumarate (Viread)
2) Tenofovir alafenamide (Vemlidy)
3) Lamivudine (Epivir)
4) Emtricitabine (Emtriva)
5) Abacavir (Ziagen)
6) Zidovudine (Retrovir)

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17
Q

Which NRTI is give to a mother via IV during birth if mother’s viral load >1000 copies/mL?

A

Zidovudine

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18
Q

MOA of NRTI

A

Competitively block (inhibit) reverse transcriptase

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19
Q

Which NRTI does not require renal dose adjustment

A

Abacavir

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20
Q

What is the first line ART regimens, if treatment-naïve

A

1 or 2 NRTIs as the backbone with an NSTI

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21
Q

Boxed warning of NRTIs

A

Lactic acidosis

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22
Q

Abacavir, tenofovir, and lamivudine all have what warning?

A

Hepatomegaly with steatosis

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23
Q

True or false: Abacavir can be used if treating both HIV and Hep B?

A

False

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24
Q

True or false: Emtricitabine can be replaced with lamivudine but they cannot be used together?

A

True

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25
Q

List all of the INSTIs

A

1) Bictegravir
2) Elvitegravir (EVG)
3) Dolutegravir (Tivicay)
4) Raltegravir

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26
Q

How far apart do INSTIs and cations need to be separated?

A

INSTIs two hours before or 6 hours after

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27
Q

MOA of INSTIs

A

Block the integrate preventing viral DNA from integrating into the hose cell DNA

28
Q

List all the in NNRTIs

A

1) Efavirenz

2) Rilpivirine

29
Q

MOA of NNRTIs

A

Inhibits reverse transcriptase enzyme by binding non-competitively

30
Q

Which NNRTIs are taken with food

A

Rilpivirine

31
Q

True or false: All NNRTIs are inducers and inhibitors except Rilpivirine

32
Q

Boxed warning of NNRTIs

A

1) Hepatotoxicity

2) Severe Rash

33
Q

Which NNRTI causes psychiatric symptoms such as abnormal dreams

34
Q

When can Rilpivirine not be used?

A

1) Viral load > 100,000 copies

2) CD4+ counts < 200

35
Q

List all the PIs

A

1) Atazanavir (Reyataz)

2) Darunavir (Prezista)

36
Q

MOA of PIs

A

Inhibit protease enzyme

37
Q

True or false: Both Atazanavir and Darunavir should be given with boosters ritonavir 100mg or cobicistat 150mg

38
Q

True or false: Atazanavir and Darunavir should be taken with food?

39
Q

Atazanavir could cause?

A

Hyperbilirubinemia, PR interval prolongation, and skin reactions

40
Q

True or false: With darunavir you must use caution with. a sulfa allergy

41
Q

Which drugs should not be used with PIs

A

1) Alfuzosin
2) Colchicine
3) Dronedarone
4) Amiodarone
5) Apixaban
6) edoxaban
7) Rivaroxaban
8) Direct-acting antivirals
9) Hormonal contraceptives
10) Lovastatin
11) Simvastatin

42
Q

List the boosters

A

1) Ritonavir (Norvir)

2) Cobicistat (Tybost)

43
Q

True or false: ritonavir and cobicistat are interchangeable

44
Q

What is the contraindication of boosters?

A

Use with narrow therapeutic index drug that is cleared via CYP3A4

45
Q

When should Stribild not be used?

A

When CrCl < 50mL/min

46
Q

What is in Stribild?

A

Elvitegravir
Cobicistat
Emtricitabine
Tenofovir disoproxil fumarate

47
Q

When should Genvoya not be used?

A

CrCl < 30mL/min

48
Q

What is in Genvoya

A

Elvitegravir
Cobicistat
Emtricitabine
Tenofovir alafenamide

49
Q

What drug is a CCR5 Antagonist?

50
Q

What is required to start Maraviroc

A

Must have tropism because it only works with CCR5-tropic disease aka CCR5 receptors are the ONLY ONES present

51
Q

How is the fusion inhibitor, Enfuvirtide given?

A

90mg SC BID

52
Q

True or false Fuzeon requires reconstitution?

53
Q

AIDS is diagnosed when?

A

CD4+ count < 200
Opportunistic infection
Kaposi’s sarcoma
HIV wasting syndrome

54
Q

PrEP is used when and which drugs are used?

A

Before high-risk activity taken daily

Truvada or Descovy

55
Q

True or false: before starting PrEP, patient should have a HIV-negative antibody test

56
Q

How often should a patient follow-up when taking PrEP?

A

Every 3 months

57
Q

Pep is used when and which drugs are used?

A

After HIV-exposure within 72 hours and taken for 28 days. Truvada + Dolutegravir or Raltegravir

58
Q

What is in Atripla?

A

Efavirenz
Tenofovir disproval fumarate
Emtricitabine

59
Q

What is in Complera?

A

Rilpivirine
Tenofovir disproval fumarate
Emtricitabine

60
Q

What is in Odefsey?

A

Rilpivirine
Emtricitabine
Tenofovir alafenamide

61
Q

What is in Epzicom?

A

Abacavir

Lamivudine

62
Q

Retrovir is the brand name of?

A

Zidovudine

63
Q

Isentress, Isentress HD is the brand name of?

A

Raltegravir

64
Q

Tivicay is the brand name of?

A

Dolutegravir

65
Q

Prezista is the brand name of?

66
Q

Reyataz is the brand name of?

A

Atazanavir

Naplex ID Section (21 decks)

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