Carbapenems

Question 1

True or false, carbapenems are reserved for multi-drug resistant gram negative infections

Answer 1

True

Question 2

What do carbapenems cover?

Answer 2

Active against most gram-positive, gram negative (including ESBL producing bacteria), and anaerobic pathogens

Question 3

What do carbapenems not cover?

Answer 3

Atypical pathogens, MRSA, VRE, C. difficile, and Stenotrophomonas

Question 4

True or false, carbapenems can be used in patients with a penicillin allergy

Answer 4

False, they should not be used in patients with a penicillin allergy

Question 5

Carbapenems have a class warning of?

Answer 5

Seizures

Question 6

What is the brand name of meropenem

Answer 6

Merrem

Question 7

Which two carbapenems should be renal adjusted at CrCl 50 mL/min

Answer 7

Doripenem

Meropenem

Question 8

What is the brand name of Ertapenem?

Answer 8

Invanze

Question 9

List all the carbapenems

Answer 9

1) Doripenem
2) Imipenem
3) Meropenem
4) Ertapenem

Question 10

Ertapenem can be diluted in only what?

Answer 10

Normal saline

Question 11

What is different about Ertapenem than the other carbapenems?

Answer 11

No coverage against pseudomonas, acinetobacter, or enterococcus

Question 12

How does Carbapenems impact valproic acid?

Answer 12

Decreases serum concentrations of valproic acid

Question 13

When should ertapenem be renally adjusted

Answer 13

CrCl 30 mL/min

Question 14

What is Imipenem combined with and why?

Answer 14

Cilastatin to prevent drug degradation by renal tubular dehydropeptidase