SUCCINYLCHOLINE (generic name) ANECTINE (brand name)

Question 1

SUCCINYLCHOLINE

Drug Class

Answer 1

DRUG CLASS

Neuro muscular blocker, depolarizing; skeletal muscle relaxant

Question 2

SUCCINYLCHOLINE

Indications

Answer 2

INDICATIONS

Rapid Sequence Intubations (RSI)

Question 3

SUCCINYLCHOLINE

Mechanism of Action

Answer 3

MECHANISM OF ACTION
Ultra-short-acting depolarizing skeletal muscle relaxant that mimics acetylcholine as it binds with the cholinergic receptors on the motor end plate, producing a phase 1 block as manifested by fasciculations.

Question 4

SUCCINYLCHOLINE

Contraindications

Answer 4

CONTRAINDICATIONS
Acute narrow-angle glaucoma, penetrating eye injuries, malignant hyperthermia. Acute injury after multisystem trauma, major burns, or extensive muscle injury. Inability to control airway or support ventilation with oxygen or support ventilation.

Question 5

SUCCINYLCHOLINE

Adverse Effects

Answer 5

ADVERSE EFFECTS
Respiratory depression, bradydysrhythmia, tachydysrhythmia, dysrhythmia, cardiac arrest, salivation, prolonged muscle rigidity, rhabdomyolysis, malignant hyperthermia, increased intraocular pressure, hyperkalemia (trauma patients)

Question 6

SUCCINYLCHOLINE

Precautions

Answer 6

PRECAUTIONS

Oxytocin, Beta Blockers and Organophosphates may potentiate effects, diazepam (Valium) can reduce duration of action

Question 7

SUCCINYLCHOLINE

Dose and Administration

Answer 7

DOSE AND ADMINISTRATION
ADULT 
1 to 1.5 mg/kg rapid IV. Repeat once if needed.
PEDI 
1 to 1.5 mg/kg rapid IV/IO
Onset of 1 minute, peak 1 to 3 minutes
Duration 5 to 10 minutes