HYDROXOCOBALAMINE (generic name)

Question 1

HYDROXOCOBALAMIN brand name

Answer 1

BRAND NAME

* CIANOKIT

Question 2

HYDROXOCOBALAMIN drug class

Answer 2

DRUG CLASS

* Antidote

Question 3

HYDROXOCOBALAMIN indications

Answer 3

INDICATIONS

* Treatment of known or suspected cyanide poisoning

Question 4

HYDROXOCOBALAMIN mechanism of action

Answer 4

MECHANISM OF ACTION

• Binds with cyanide to form non toxic cyanocobalamin (vitamin B12), preventing its toxic effects
• Excreted renally

Question 5

HYDROXOCOBALAMIN contraindications

Answer 5

CONTRAINDICATIONS

* None in the emergency setting

Question 6

HYDROXOCOBALAMIN adverse effects

Answer 6

ADVERSE EFFECTS

• Hypertension
• Allergic reactions
• GI bleeding
• Nausea
• Vomiting
• Dyspepsia
• Dyspnea
• Dizziness
• Headache
• Injection site reaction

Question 7

HYDROXOCOBALAMIN precautions

Answer 7

PRECAUTIONS

* Not compatible in the same IV line with many other medications

Question 8

HYDROXOCOBALAMIN dose and administration

Answer 8

DOSE AND ADMINISTRATION
* ADULT
5 grams IV infusion over 15 minutes at a rate of 15 ml/min. May repeat x1 at the same dose to a maximum of 10 mg
* PEDI
70 mg/kg IV. Maybe repeated one time at the same dose