STRUCTURE OF PRO INSULIN

Question 1

What happens when there is cleaving of the connecting peptide?

Answer 1

Results in pro insulin being converted into insulin

Question 2

What are A and B chain connected by?

Answer 2

Connecting peptide

Question 3

Active insulin and inactive c- peptide are packaged into what?

Answer 3

Secretary granules

Question 4

What are secretary granules released from?

Answer 4

Beta cells (simultaneously)

Question 5

Why are secretary granules released from beta cells?

Answer 5

Elevations in blood glucose

Question 6

Blood glucose enters the cell though what?

Answer 6

Glucose Transporter

Question 7

Blood glucose is metabolized to form what?

Answer 7

Adenosine triphosphate or ATP through phosphorylation by an enzyme called glucokinase

Question 8

What is ATP needed for?

Answer 8

Closes the potassium channels an depolarize the cell

Question 9

What happens when the beta cell is depolarized ?

Answer 9

Calcium charnels open and insulin is secreted

Question 10

Insulin secretion is deceased when blood glucose levels are _______, an increased when blood glucose levels are ______.

Answer 10

Lower.
Higher.

Question 11

1st phase:

Answer 11

Stored performed insulin is secreted

Question 12

2nd phase:

Answer 12

begins around 2 mins and increases slowly for at least 60 minutes or until stimulus ceases
- insulin released in 2nd phase is newly synthesized insulin