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Drew 921 > Structure & Function of the Vasculature > Flashcards

Structure & Function of the Vasculature Flashcards

1
Q

Describe the composition of the tunica intima.

A

Single layer endothelium

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2
Q

Describe the composition of the tunica media.

A

Thick, elastic proteins

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3
Q

Describe the composition of the serosa adventita.

A

Acellular, glycosylated collagen & fibers

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4
Q

What is the equation for compliance?

A

C = (deltaV) / (deltaP)

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5
Q

What is the equation for pulse pressure?

A

PP = SBP - DBP

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6
Q

What is pulse wave velocity a measure of?

A

It is a measure of arterial resistance

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7
Q

What factors contribute to the good exchange capability of capillaries?

A

1) large surface area
2) short diffusion distance
3) slow flow

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8
Q

What are the types of transcytosis?

A

1) clarithrin-dependent receptor binding

2) caveolae system

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9
Q

Describe the characteristics of the plasmalemma associated with the caveolae system.

A

Highly enriched in…

1) caveolin
2) phsopholipid
3) sphingolipid
4) cholesterol

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10
Q

How are arterioles regulated?

A

SNS innervation

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11
Q

What kinds of molecules use diffusion to cross membrane?

A

Lipid & water soluble molecules

water-soluble things must use pores!

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12
Q

Define bulk flow of substance out of capillaries.

A

The free flow of H2O & solutes through the intracellular cleft to maintain normal blood volume

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13
Q

What is a rivulet?

A

A pool of water in the extracellular space

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14
Q

What is the Starling Pc term?

A

capillary pressure

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15
Q

What is the starling (PI)ip term?

A

Plasma colloid osmotic pressure

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16
Q

What is the starling (PI)if term?

A

interstitial fluid colloid osmotic pressure

17
Q

What is the starling Kf term?

A

Capillary filtration coefficient

18
Q

What is the filtration equation?

A

Filtration = NFP * Kf

19
Q

How does Kf vary / how is it regulated across tissues?

A

1) # of pores
2) size of pores
3) # of perfused capillaries

20
Q

What starling terms are constant at arterial & venous ends of capillaries?

A

(PI)ip
(PI)if
Pif

21
Q

What is the capillary pressure @ the arterial end of a capillary?

A

30 mmHg

22
Q

What is the capillary pressure @ the venous end of a capillary?

A

10 mmHg

23
Q

What is the net outward force at the arterial end of a capillary?

A

13 mmHg

24
Q

What is the net inward force at the venous end of the capillary?

A

7 mmHg

25
Q

What is the mean capillary pressure?

A

17.3 mmHg

26
Q

What is the net outward force along the entire capillary (average)

A

0.3 mmHg

27
Q

How does capillary permeability vary in brain, liver, kidney, & GI?

A

Brain: very tight
liver, kidney: very leaky
GI: compromise–allows nutrient flux w/o pathogen entry

28
Q

How is vascular tone regulated?

A

SNS & delayed compliance

29
Q

What factors influence venous return?

A

1) skeletal muscle pump
2) respiratory pump
3) sympathetic activity

Drew 921 (33 decks)

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