Block 2b Acquired Immunity

Question 1

5 kinds of antibody

Answer 1

M, G, A, D, E

Question 2

What is the most prevalent antibody?

Answer 2

G (75%)

Question 3

Describe the composition of an antibody?

Answer 3

2 heavy & 2 variable light chains w/ disulfide connections

Question 4

What are the effects of antibody?

Answer 4

1) direct antigen attack

2) complement system activation

Question 5

How do antibodies attack antigens directly?

Answer 5

1) agglutination
2) precipitation
3) neutrilzation
4) lysis

Question 6

What complement factors promote opsonization?

Answer 6

c3b

Question 7

What complement factors promote mast cell & basophil activation?

Answer 7

c3a, c4a, c5a

Question 8

What complement factors promote leukocyte chemotaxis?

Answer 8

c5a

Question 9

What complement factors promote cell lysis?

Answer 9

c5b6789

Question 10

What are the effects of the copmlement system?

Answer 10

agglutination, neutralization, inflammation

Question 11

How is the complement system activated?

Answer 11

Ag/Ab (Fab) binding activates Fc domain to bind to C1

Question 12

What are APCs?

Answer 12

macrophages
B cells
dendritic cells

Question 13

Cytotoxic T cells have what class of MHC proteins?

Answer 13

MHC-1

Question 14

T helper cells have what class of MHC proteins?

Answer 14

MHC-2

Question 15

Function of MHC1 T cells?

Answer 15

lysis (quicker than phago)

not immediately apoptotic

Question 16

What cells are implicated in autoimmune dz?

Answer 16

Cytotoxic T

Question 17

What is the effect of lymphokine production by Th cells?

Answer 17

1) proliferate cytotoxic & suppressor Ts
2) proliferate Bs
3) activate macrophages

Question 18

What lymphokines are secreted by Th cells?

Answer 18

1) interleukins – 2 & 12

2) interferon gamma

Question 19

What lymphocytes are the target of HIV?

Answer 19

CD4+ Th cells (MHCII)

Question 20

What is required for the T cell response?

Answer 20

MHC & APC Ag presentation & cell-cell adhesion proteins

Question 21

What happens in the B cell response?

Answer 21

1) lymphoid B proliferation
- - ER & Golgi production
3) antibody secretion

Question 22

What genes make up the alpha chain of the TCR?

Answer 22

V & J recombined to make C

Question 23

What genes make up the beta chain of the TCR?

Answer 23

VDJ recombined to make C

Question 24

How do APCs aid in proliferating activated Ts?

Answer 24

IL-1