Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Dermatology > Structure and Function 3 > Flashcards

Structure and Function 3 Flashcards

You may prefer our related Brainscape-certified flashcards:
Dermatology Board Prep flashcards
1
Q

Support, anchorage, adhesion, growth and
differentiation of epidermal cells

Semi-permeable membrane acting as
barrier and filter

A

Dermoepidermal junction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Epidermolysis bullosa (simplex and dystrophic) affect which layer of the skin?

A

Dermo-epidermal junction

-due to a mutation in one of the proteins in the DEJ

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Name 3 conditions with auto-antibodies to the proteins in the DEJ?

A

Pemphigus
Pemphigoid
Dermatitis herpetiformis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Epidermolysis bullosa simplex

Chromosomes 12q, 17q

A

Autosomal dominant
Superficial blistering
Scarring absent
Often shows intermittent blsitering especially in hot weather

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Epidermolysis Bullosa Dystrophica

A

Deeper blistering associated with scarring
Skin, nails, mucosa and often the larynx involved

Repeated scarring results in squamous cell carcinoma and pts often die from complications in early life

Life expectancy significantly reduced
Recessive form is far worse than the dominat form

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which bullous disease shows positive immunofluorescence?

A

Bullous pemphigoid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Components of the dermis?

A

Cells - mainly fibroblasts, macrophages, mast cells, lymphocytes, Langerhans cells

Fibres – collagen, elastin

Ground substance

Blood vessels, lymphatics, nerves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Main type of cells in the dermis?

A

Fibroblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What type of cell secretes collagen?

A

Fibroblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

These cells are scavengers and are involve in antigen presentation

A

Macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cells involved with immune reactions

A

Lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Langerhans cells do what

A

Antigen presentation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is dermogrpahism? (really cool)

A

Its like being able to write on your skin, whenever you stroke hard/scratch, it goes really red

Because of mast cell activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which layer of the skin is responsible for photo aging?

A

The fibres in the dermis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Flow of blood

A 
Arteriole -->
Precapillary sphincter -->
Arterial capillaries -->
Venous capillaries -->
Post-capillary venules -->
Collecting venules
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is an angioma?

A

Localised overgrowth of blood vessels
Eg: port wine stain, “stork marks”
(capillary or cavernous haemangiomas)

17
Q

Which layer are the blood vessels found in?

A

The dermis

18
Q

Histological findings of angioma

A

Dilated vascular spaces

19
Q

Pacinian receptors sense what?

A

Pressure

these are dound slightly deeper in the dermis than the meissners

20
Q

Meissners corpuscles sense what?

A

Vibration

21
Q

Widely distributed:
largest glands present on face and chest

Hormone sensitive – quiescent pre-puberty

Produce sebum: squalene, wax esters, triglycerides and free fatty acids

Mainly open onto hair follicle

Functions:
control moisture loss
protection from bacterial and fungal infection

A

Sebaceous glands

22
Q

Function of sebaceous glands?

A

Control moisture loss

Protection from bacterial and fungal infection

23
Q

A mixture of increased sebum, blocked ducts and bacterial activity?

A

Acne

24
Q

Develop as part of pilosebaceous unit

Axillae and perineum

Androgen dependent

Produce oily fluid odour after bacterial decompostion

Scent glands

A

Apocrine glands

25
Q

Apocrine glands are dependent on which hormone?

A

Androgen

26
Q

Whole skin surface palms, soles and axillae in particular

Sympathetic cholinergic nerve supply – mental, thermal and gustatory stimulation

Ultrafiltration : can be > 10L per day 2 - 4 million glands = 100g (= one kidney) NaCl + HCO3 reabsorbed - hypotonic fluid

Functions: cooling by evaporation moisten palms / soles to aid grip

A

Eccrine glands

27
Q

Nerve supply to the eccrine sweat glands?

A

Sympathetic cholinergic

mental, thermal and gustatory regulation

28
Q

Function of eccrine glands?

A

Cooling by evaporation

Moisten palms/soles to aid grip

Dermatology (27 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions