Muthu skin cancer Flashcards
Which professions more likely to get SCC?
SCC: >90% on head, neck, hands, forearms
Outdoor workers, farmers, sailors, recreational
Childhood sunburn increases melanoma risk by what
4 fold
Sunscreen reduces which type of cancer?
SCC (not BCC)
Phototoxic drugs
Psoralen Voriconazole Vemurafenib Azathioprine Thiazide diuretics Anti-TNF NSAIDS BRAF inhibitors
Environmental carcinogens
Coal tar Smoking Ionising radiation Arsenic Trauma Chronic ulceration
Aside from the obvious skin conditions, what other diseases predispose to cancer?
Ankylosing spondylitis
Scalp ringworm
Previous skin cancer
(HPV infection)
What percentage of sunburn occurs in the first 18 years of life?
Up to 80%
Gorlin’s syndrome
Naevoid basal cell carcinoma
Naevoid basal cell carcinom
Gorlin syndrome
photosensitivity skin cancers on UV-exposed sites neurological degeneration Increased risk of other cancers Defect in one of seven Nucleotide Excision Repair (NER) genes (XPA - G)
Xeroderma pigmentosum
Which type of gene is affected in xeroderma pigmentosum?
Nucleotide excision repair gene (XPA-G)
Median age for cancer onset in xeroderma pigmentosum?
Age 8
Gorlin’s syndrome inheritance?
Autosomal dominant
Features of Gorlin’s syndrome
- early onset/multiple BCCs
- jaw cysts
- palmar pits
- ectopic calcification falx cerebri
(Minor features: skeletal abnormality, OFC >97th centile, cardia/ovarian fibroma, medulloblastoma)
Hereditary type VII collagen deficiency
Recessive epidermolysis bullosa
high risk patients
